OBJECTIVE To evaluate the efficacy and safety of adjunctive eslicarbazepine acetate (ESL) in patients with refractory partial-onset seizures. METHODS This randomized, placebo-controlled, double-blind, parallel-group, phase III study was conducted at 173 centers in 19 countries, including the United States and Canada. Eligible patients were aged ≥16 years and had uncontrolled partial-onset sei...

PURPOSE Eslicarbazepine acetate (ESL) is a once-daily (QD) oral antiepileptic drug (AED) indicated for partial-onset seizures (POS). Clinical studies of gradual conversion to ESL 1,200 and 1,600 mg QD monotherapies were previously conducted in patients with POS who were not well-controlled by 1 or 2 AEDs. This report describes modeling and simulation of plasma eslicarbazepine (primary active me...

TGF-β is abundantly produced in the skeletal system and plays a crucial role in skeletal homeostasis. E-selectin ligand-1 (ESL-1), a Golgi apparatus-localized protein, acts as a negative regulator of TGF-β bioavailability by attenuating maturation of pro-TGF-β during cartilage homeostasis. However, whether regulation of intracellular TGF-β maturation by ESL-1 is also crucial during bone homeost...

Once thought to be a structure of small size and uncertain significance, the endothelial glycocalyx is now known to be an important regulator of endothelial function. Studies of the systemic vasculature have demonstrated that the glycocalyx forms a substantial in vivo endothelial surface layer (ESL) critical to inflammation, barrier function, and mechanotransduction. The pulmonary ESL is signif...

The use of a computer assisted language learning (CALL) to facilitate ESL has a history dating back to the 1950’s. With advances in technology CALL based curriculums have become more accessible to educators in the ESL field. CALL based programs are being used to improve reading, comprehension, writing skills and pronunciation skills of students engaged in ESL studies. The focus of this paper wi...

Interior surfaces of capillaries are lined with macromolecules forming an endothelial surface layer (ESL). A theoretical model is used to investigate effects of flow velocity on motion and axisymmetric deformation of red blood cells in a capillary with an ESL. Cell deformation is analyzed, including effects of membrane shear and bending elasticity. Plasma flow around the cell and through the ES...

OBJECTIVE Exercise-induced airway obstruction in pediatric patients is a unique phenomenon with multiple potential etiologies. An accurate diagnosis can be challenging to establish in pediatric patients because they are frequently asymptomatic at rest. Exercise stress laryngoscopy (ESL) is a modality by which pediatric patients can be evaluated under physiologic conditions that produce their sy...

This study examined the basic literacy skills and related processes of 1stthrough 4th-grade children speaking English as a 1st language (L1) and English as a 2nd language (ESL). The performances of the L1 and ESL children on phonological awareness, word and pseudoword reading, and word and pseudoword spelling tasks were highly similar. The ESL children were at an advantage with regard to lexica...

The breadth and depth of ESL learners’ vocabulary knowledge and their comprehensive linguistic competence are not well studied in current literatures on vocabulary studies. This paper explores the creditability of depth and breadth of ESL learners’ vocabulary knowledge as an indicator of their overall linguistic competence and the correlation between depth and breadth of ESL learners’ vocabular...

BACKGROUND Psychiatric and behavioral side effects (PBSEs) are a major cause of antiepileptic drug (AED) withdrawal. Levetiracetam (LEV) is a recognized first-line AED with good seizure outcomes but recognized with PBSEs. Eslicarbazepine (ESL) is considered to function similarly to an active metabolite of the commonly used carbamazepine (CBZ). Carbamazepine is used as psychotropic medication to...