BACKGROUND It is well established that the esophageal distention (ED) leads to gastric relaxation, partly by vago-vagal reflex, but till now, the effect of ED on gastric acid secretion has not been investigated. The aim of this study was to investigate the effect of ED on basal and stimulated gastric acid secretion. METHODS Adult male Wistar rats (200-240 g) were deprived of food but not the ...

The response of the normal human esophagus to an obstructing intraluminal bolus was investigated and compared to the response evoked by transient intraluminal distention. A balloon, immobilized within the esophagus by external attachment to a force transducer, was inflated with from 3 to 25 ml of air for from 3 to 210 sec. Pressure phenomena occurring in the esophagus were simultaneously record...

abstract introduction: there are many studies about the inhibitory effect of the esophageal distention (ed) on gastric motility. recently, it has been shown that ed decreases the gastric secretions. it is well established that the inhibitory effect of ed is mediated by activation of vago-vagal inhibitory reflex. however, there is not any investigation about the effect of the reflex on the gastr...

A 4-month-old infant was diagnosed with esophageal atresia and tracheoesophageal fistula. He was admitted to our hospital because of progressive poor findings and repeated aspiration pneumonia after surgical repair. An esophagogram demonstrated severe esophageal stricture. Flexible endoscopic dilatation was performed under general anesthesia, but sudden onset respiratory distress and progressiv...

Activation of gastric vagal mechanoreceptors by distention is thought to be the trigger for transient lower esophageal sphincter relaxations (TLESR), which lead to gastroesophageal reflux. The contribution of higher-threshold gastric splanchnic mechanoreceptors is uninvestigated. GABA(B) receptor agonists, including baclofen, potently reduce triggering of TLESR by low-level gastric distention. ...

Clinical studies showed that GABA(B) receptor agonists improve symptoms in patients with gastroesophageal reflux disease. One proposed mechanism of this effect is direct inhibition of the gastroesophageal vagal tension mechanosensors by GABA(B) agonists leading to reduction of reflux. In addition to tension mechanosensors, the vagal nodose ganglion supplies the esophagus with nociceptive C-fibe...

A 72-year-old man with pancreatic cancer presented coffee-ground emesis for 2 days. Computed tomography of abdomen oral contrast showed gastric distention, transition point at level the bulb and large volume ascites. Endoscopy severe diffuse exudative esophagitis involving most esophagus areas black discoloration mid distal edematous (Figures B). infiltrating mass, consistent known cancer, was ...

Low-tidal-volume ventilation strategies are clearly beneficial in patients with acute lung injury and acute respiratory distress syndrome, but the optimal level of applied positive end-expiratory pressure (PEEP) is uncertain. In patients with high pleural pressure on conventional ventilator settings, under-inflation may lead to atelectasis, hypoxemia, and exacerbation of lung injury through "at...

This study aimed to investigate affective modulation of eye blink startle by aversive visceral stimulation. Startle blink EMG responses were measured in 31 healthy participants receiving painful, intermittent balloon distentions in the distal esophagus during 4 blocks (positive, negative, neutral or no pictures), and compared with startles during 3 'safe' blocks without esophageal stimulations ...

OBJECTIVE To determine the usefulness of pneumoesophagography, compared with that of survey radiography, for characterization of esophageal pathological changes in dogs with endoscopically confirmed intraluminal Spirocerca lupi nodules in the caudal portion of the esophagus. DESIGN Diagnostic test evaluation. ANIMALS 30 dogs with endoscopically confirmed spirocercosis. PROCEDURES Dorsoven...