Methods Seventy-two patients with severe, medication-refractory essential tremor have been enrolled across seven international centers. Standard assessments of tremor severity and disability will be obtained before and after the procedure. Patients are randomized in a one-to-three fashion to receive either sham procedure or MR-guided focused ultrasound thalamotomy. The Tremor Research Group, ne...

ii Abbreviations iv Manuscripts vi Populärvetenskaplig sammanfattning på svenska vi

BACKGROUND Essential tremor (ET) is often familial and phenotypic features may be shared within families. Cranial (neck, voice, and jaw) tremor is an important feature of ET. We examined whether cranial tremor aggregates in ET families, after controlling for other factors (age, tremor severity, and duration). METHODS Among ET probands and relatives enrolled in a genetic study at Columbia Univ...

A rhythmic tremor at about 10 c./sec. is a wellknown feature of muscular contraction in healthy adults. In some subjects the amplitude of the tremor is such that it is discernible by the naked eye, while in others sensitive methods of recording are required for its detection. While studying this phenomenon Marshall and Walsh (1956) noticed that the tremor in six normal children was slower than ...