نتایج جستجو برای: estrogen deficiency
تعداد نتایج: 178203 فیلتر نتایج به سال:
Estrogen deficiency is one of the most frequent causes of osteoporosis in women and a possible cause of bone loss in men. But the mechanism involved remains largely unknown. Estrogen deficiency leads to an increase in the immune function, which culminates in an increased production of tumor necrosis factor (TNF) by activated T cells. TNF increases osteoclast formation and bone resorption both d...
Clinical evidences show sex differences in risk of developing depressive disorders as well as effect of antidepressants in depression treatment. However, whether such a sex-dependent risk of depression and efficacy of antidepressants is dependent on endogenous estrogen level remain elusive. The aim of this study is to explore the molecular mechanisms of sex differences in antidepressant duloxet...
Postmenopausal disorders are frequently observed in various organs, but their relationship with estrogen deficiency and mechanisms remain unclear. As tissue-specific stem cells have been found to express estrogen receptors, we examined the hypothesis that estrogen deficiency impairs stem cells, which consequently contributes to postmenopausal disorders. Six-week-old C57BL/6 female mice were ova...
Lipid metabolism disorders commonly occur during menopause. Estrogen deficiency has been shown to lead excessive energy intake and abnormal lipid in ovariectomized rats, resulting obesity. Probiotics exhibit anti-obesity properties, their underlying mechanism widely reported. In this study, we demonstrated the metabolic benefits of Lactobacillus plantarum CCFM1180 suppressing appetite, c...
Estrogen deficiency is associated with increased incidence of cardiovascular diseases. But merely estrogen supplementary treatment can induce many severe complications such as breast cancer. The present study was designed to elucidate molecular mechanisms underlying increased susceptibility of arrhythmogenesis during myocardial infarction with estrogen deprivation, which provides us a new targe...
CONTEXT Protein S deficiency and mesenteric venous thrombosis have been described in association with ischemic and/or necrotic bowel. Thrombophilic familial protein S deficiency is known to be amplified by estrogen replacement therapy. Pancreatic ischemia studies have revealed elevated amylase and lipase levels but not hyperglucagonemia. We postulate that estrogen replacement therapy leading to...
Osteoarthritis (OA) affects all articular tissues and finally leads to joint failure. Although articular tissues have long been considered unresponsive to estrogens or their deficiency, there is now increasing evidence that estrogens influence the activity of joint tissues through complex molecular pathways that act at multiple levels. Indeed, we are only just beginning to understand the effect...
Introduction. The elderly are at high risk of developing osteosarcopenia, which is characterized by the coexistence osteoporosis and sarcopenia. There many factors that affect interaction between bones muscles: genetics, hormones, nervous system, aging, cardiac rhythm, nutrition. Pathophysiology osteosarcopenia. Risk include: age 50 years over, sex, Caucasian race, genetic predisposition, short...
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