نتایج جستجو برای: estrogen response element

تعداد نتایج: 1193709  

Journal: :Molecular human reproduction 2002
Christina T Teng Wesley Gladwell Clara Beard David Walmer Ching S Teng Robert Brenner

We have previously shown that the estrogen responsiveness of the human lactoferrin gene in a transient transfection system is mediated through an imperfect estrogen response element (ERE) and a steroidogenic factor 1 binding element (SFRE) 26 bp upstream from ERE. Reporter constructs containing SFRE and ERE respond to estrogen stimulation in a dose-dependent manner, whereas mutations at either ...

Journal: :Molecular endocrinology 1999
W Xie H Hong N N Yang R J Lin C M Simon M R Stallcup R M Evans

In this report, we demonstrate that, in contrast to most previously characterized nuclear receptors, hERR1 and hERR2 (human estrogen receptor-related protein 1 and -2) are constitutive activators of the classic estrogen response element (ERE) as well as the palindromic thyroid hormone response element (TRE(pal)) but not the glucocorticoid response element (GRE). This intrinsically activated sta...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2013
Xi Zhang Kaori Tanaka Jiusheng Yan Jing Li Danni Peng Yuanyuan Jiang Zhe Yang Michelle C Barton Hong Wen Xiaobing Shi

Estrogen receptor alpha (ERα) is a ligand-activated transcription factor. Upon estrogen stimulation, ERα recruits a number of coregulators, including both coactivators and corepressors, to the estrogen response elements, modulating gene activation or repression. Most coregulator complexes contain histone-modifying enzymes to control ERα target gene expression in an epigenetic manner. In additio...

Journal: :International journal of oncology 1995
G Zachos V Zoumpourlis C Sekeris D Spandidos

There is evidence that hormone regulation of cellular oncogenes plays an essential role in human cancer. The c-H-ras gene is implicated through both mutation and abnormal gene expression in many types of human cancer. Computer scanning of this gene has revealed two putative hormone response motifs: A possible Glucocorticoid Response Element (GRE) at position 1261 of the first intron of the H-ra...

Journal: :auditory and vestibular research 0
sahar avizheh department of audiology, school of rehabilitation, tehran university of medical sciences, tehran, iran mehdi akbari department of audiology, school of rehabilitation sciences, iran university of medical sciences, tehran, iran jamileh fatahi department of audiology, school of rehabilitation, tehran university of medical sciences, tehran, iran akram pourbakht department of audiology, school of rehabilitation sciences, iran university of medical sciences, tehran, iran shohreh jalaie biostatistics, school of rehabilitation, tehran university of medical sciences, tehran, iran kianoush sheikholeslami department of surgery, section of neuro-oncology, robert wood johnson university hospital, cancer institute of new jersey, rutgers university, new brunswick, new jersey, usa

background and aim: the sexual hormones alter during menstrual cycle and pregnancy. despite the physiological benefits of these changes, their adverse effects on hearing system such as hearing loss and vertigo have been reported. therefore, in this study, the auditory brainstem responses (abr) were investigated during physiological hormonal variations in the menstrual cycle as well as pregnancy...

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