OBJECTIVE To investigate if continuation rates in first-time users of oral hormonal contraceptives differed between different formulations and to measure if the rates were related to the prescribing categories, that is, physicians and midwives. DESIGN A longitudinal national population-based registry study. SETTING The Swedish prescribed drug register. PARTICIPANTS All women born between ...

Estrogen-induced cholestasis is characterized by impaired hepatic uptake and biliary bile acids secretion because of changes in hepatocyte transporter expression. The induction of heme oxygenase-1 (HMOX1), the inducible isozyme in heme catabolism, is mediated via the Bach1/Nrf2 pathway, and protects livers from toxic, oxidative and inflammatory insults. However, its role in cholestasis remains ...

Each active light yellow tablet contains: Ethinylestradiol 30 micrograms Drospirenone 3 mg For full list of excipients, see section 6.1 List of excipients. 3. PHARMACEUTICAL FORM YASMIN active tablet Light yellow round film-coated tablets marked on one side with the letters “DO” in a regular hexagon, each containing drospirenone 3 mg and ethinylestradiol 30 μg. YASMIN placebo tablet White, roun...

Environmental Protection includes programs that are aimed to reducing risks the environment from hazardous materials and chemical wastes. Nowadays, 17α-ethinylestradiol, a synthetic estrogen, has become one of most commonly used active ingredients for oral contraception, interfere with normal functioning endocrine systems, thus affecting reproduction development in wildlife. The fresh water foo...

Several environmental xenobiotics have been found to affect the metamorphosis of amphibians. In this study we exposed tadpoles of the Common frog Rana temporaria from hatching to metamorphosis to two known endocrine disruptors, the estrogenic pharmaceutical 17 -ethinylestradiol and the antiandrogenic/antiestrogenic fungicide prochloraz to determine their effect on 1) days to metamorphosis and s...

ABSTRACT To determine the presence of emergent contaminants in aquatic environments and to evaluate responses dominant taxa benthic macrofauna, seven stations were sampled along three rivers that serve as public water suppliers sampling campaigns, Upper Iguassu Basin, Brazil. Concentrations ethinylestradiol, fenofibrate, ibuprofen triclosan detected sediment. correlate patterns distribution abu...

contraceptive patches have become a frequently used contraceptive method. we present a mathematical model that describes the serum concentration profiles of norelgestromin (ngmn) and ethinylestradiol (ee) released from the contraceptive patch ortho evra®. we propose a simple one-compartment model based on pharmacokinetics data reported in previous studies. the model assumes a time-dependent rel...

OBJECTIVE To examine the effect of oxandrolone and the timing of pubertal induction on final height in girls with Turner's syndrome receiving a standard dose of growth hormone. DESIGN Randomised, double blind, placebo controlled trial. Setting 36 paediatric endocrinology departments in UK hospitals. PARTICIPANTS Girls with Turner's syndrome aged 7-13 years at recruitment, receiving recombin...

In this open-label, randomized study we compared the influence of a new oral contraceptive containing 30 microg ethinylestradiol and 3 mg drospirenone (Yasmin) with a reference preparation containing 30 microg ethinylestradiol and 150 microg desogestrel (Marvelon) on variables of carbohydrate metabolism by means of oral glucose tolerance tests at baseline and in the 6th and 13th treatment cycle...

BACKGROUND Dysmenorrhea is a common condition in women, which is characterized by menstrual pain. Low-dose estrogen/progestin combined oral contraceptives have been shown to reduce the severity of dysmenorrhea symptoms, and a 28-day cyclic regimen of ethinylestradiol/drospirenone (28d regimen) is approved for this indication in Japan. AIM The aim of this study was to assess the safety and eff...