Pefloxacin mesylate is a flouroquinolone antibacterial drug effective in the treatment of bacterial conjunctivitis. The objective of the present work was to develop ocular inserts of pefloxacin mesylate and evaluate their potential for sustained ocular delivery. Reservoir-type ocular inserts were prepared by the film casting technique in teflon coated Petri dishes and characterized in vitro by ...

Purpose: The aim of the work was to prepare nitrendipne-loaded Eudragit RL 100 microspheres to achieve sustained release nitrendipine. Method: Nitrendipne-loaded Eudragit RL 100 microspheres were prepared by an emulsion-solvent evaporation method using ethanol/liquid paraffin system. The resultant microspheres were evaluated for average particle size, drug loading, in vitro drug release and rel...

Matrix type transdermal therapeutic systems (TTS) of glibenclamide were formulated using polymers Eudragit RL 100, ethyl cellulose, PVP K-30, and polyvinyl acetate, and citral was used as the penetration enhancer. The polymer films were formulated with Eudragit RL 100 and PVP K-30 in different ratios and subsequently subjected to ex vivo studies (drug permeation through rat skin) followed by in...

Effervescent multiple-unit floating drug delivery systems (muFDDSs) consisting of drug (lorsartan)- and effervescent (sodium bicarbonate)-containing pellets were characterized in this study. The mechanical properties (stress and strain at rupture, Young's modulus, and toughness) of these plasticized polymeric films of acrylic (Eudragit RS, RL, and NE) and cellulosic materials (ethyl cellulose (...

The present study was designed to investigate the effect of different types of coating polymers such as Eudragit RL 30D, Eudragit RS 30D, Eudragit NE 30D, Surelease, and Kollicoat SR 30D on physical properties and release pattern of salbutamol sulphate (SS) pellets which were prepared by Extrusion-Spheronization technology. All the polymers used in coating solution were in aqueous dispersion fo...

OBJECTIVES The aim of this study was to investigate the possibility of production of ibuprofen pellets with high amount of rate retarding polymer by aid of PEG400 as plasticizer. MATERIALS AND METHODS Polyethylene glycol (PEG400) in concentrations of 1, 3 or 5% w/w with respect to Eudragit RL was used in production of pellets containing 60% ibuprofen and 40% excipient (2% polyvinylpyrrolidone...

Oral mucosal lesions are related to several etiologies, including trauma, infection, and immunologic and neoplastic diseases. Their prevalence varies greatly depending on ethnicity, gender, and exposure to risk factors. Currently, most oral mucosal lesions are treated with creams, mouthwashes, or gels containing suitable drugs. However, topical medications may be relatively ineffective as they ...