نتایج جستجو برای: eudragit rspo
تعداد نتایج: 918 فیلتر نتایج به سال:
The Wnt/β-catenin signaling pathbway controls many important biological processes. R-Spondin (RSPO) proteins are a family of secreted molecules that strongly potentiate Wnt/β-catenin signaling, however, the molecular mechanism of RSPO action is not yet fully understood. We performed an unbiased siRNA screen to identify molecules specifically required for RSPO, but not Wnt, induced β-catenin sig...
دیلتیازم هیدروکلراید یک مهارکننده کانال کلسیمی است که به طور وسیعی در درمان فشارخون بالاو آنژین پکتوریس و بعضی از انواع آریتمی کاربرد دارد. این دارو نیمه عمر کوتاهی دارد و در محیط اسیدی معده (1.2=ph)پایدار بوده و با افزایش ph تخریب می گردد.بنابراین هدف از طراحی یک سیستم دارورسانی شناورشونده برای افزایش فراهمی زیستی و کاهش تعداد دفعات مصرف در روز آن از طریق افزایش زمان توقف دارودر معده میباشد.بد...
Formulation and Pharmacokinetic Evaluation of Microcapsules Containing Pravastatin Sodium Using Rats
Pravastatin Sodium has a cholesterol lowering agent. It has shorter half-life and undergoes first-pass metabolism. Frequent dose is required in case of conventional dosage form. The purpose of the study is to formulate and evaluate microcapsules containing Pravastatin Sodium by complex with cholestyramine resins coated with Eudragit RLPO and Eudragit RSPO polymers for achieving control release....
Diffusion and Swelling Measurements in Pharmaceutical Powder Compacts Using Terahertz Pulsed Imaging
Tablet dissolution is strongly affected by swelling and solvent penetration into its matrix. A terahertz-pulsed imaging (TPI) technique, in reflection mode, is introduced as a new tool to measure one-dimensional swelling and solvent ingress in flat-faced pharmaceutical compacts exposed to dissolution medium from one face of the tablet. The technique was demonstrated on three tableting excipient...
Article history: Received on: 08/10/2014 Revised on: 21/10/2014 Accepted on: 08/12/2014 Available online: 28/03/2015 In recent years oral controlled delivery systems have gained increased importance and interest since it is necessary to improve the systemic absorption of the drugs and patient compliance. In addition, controlled delivery systems maintain uniform drug levels, reduce dose and henc...
The present research concerns the formulation and evaluation of sustained release pellets filled capsule of opioid analgesic, Tramadol HCl. Development of sustained release dosage form is to maintain therapeutic blood levels of the drug for extended period of time. Sustained release formulation provides uniform concentration at absorption site, maintains plasma concentration within a therapeuti...
The present investigation involves formulation and evaluation of microspheres with Repaglinide as model drug for prolongation of drug release time. An attempt was made to prepare microspheres of Repaglinide by Quasi emulsion solvent diffusion technique, with a view to deliver the drug at sustained or controlled manner in gastrointestinal tract and consequently into systemic circulation. The mic...
R-spondin (Rspo)s proteins are a new group of Wnt/beta-catenin signaling agonists. These signaling molecules are known to be involved in the developmental stages of skeletal system. Recent studies in various murine osteoblast models have proposed that Rspo 1 may interact with Wnt signaling pathway to induce differentiation in osteoblasts. Though findings in murine osteoblasts implicate a synerg...
The R-Spondin (RSpo) family of secreted proteins is implicated in the activation of the Wnt signaling pathway. Despite the high structural homology between the four members, expression patterns and phenotypes in knockout mice have demonstrated striking differences. Here we dissected and compared the molecular and cellular function of all RSpo family members. Although all four RSpo proteins acti...
The use of colloidal particles to prepare and stabilize emulsions, known as "Pickering emulsions “, has aroused growing interest in recent years. Pickering Ramsden demonstrated at the beginning last century feasibility surfactant-free presence these is called Emulsions". This concept stabilized by solid experiencing renewed nowadays given many advantages it offers good stability, environmental ...
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