objective(s):estrogen (e2) has neuroprotective effects on blood-brain-barrier (bbb) after traumatic brain injury (tbi). in order to investigate the roles of estrogen receptors (ers) in these effects, er-α antagonist (mpp) and, er-β antagonist (phtpp), or non-selective estrogen receptors antagonist (ici 182780) were administered. materials and methods: ovariectomized rats were divided into 10 gr...

In the present study, the effect of Datura steramonium (DS) seed extract on acute inflammation induced by formalin injection was investigated. For this purpose, two control and treatment groups were selected and in order to induce pain, formalin (50 µl, 2.5%) was applied to the plantar surface of hind paws. In treatment group, 20-30 min before formalin injection, the DS seed extract was used i....

In the present study, the effect of Datura steramonium (DS) seed extract on acute inflammation induced by formalin injection was investigated. For this purpose, two control and treatment groups were selected and in order to induce pain, formalin (50 µl, 2.5%) was applied to the plantar surface of hind paws. In treatment group, 20-30 min before formalin injection, the DS seed extract was used i....

Genetic defects in a number of components of the dystrophin-glycoprotein complex (DGC) lead to distinct forms of muscular dystrophy. However, little is known about how alterations in the DGC are manifested in the pathophysiology present in dystrophic muscle tissue. One hypothesis is that the DGC protects the sarcolemma from contraction-induced damage. Using tracer molecules, we compared sarcole...

PURPOSE The purpose of this study was to evaluate the permeability of the blood-brain barrier after sonication by pulsed high-intensity focused ultrasound and to determine if such an approach increases the tumor:ipsilateral brain permeability ratio. MATERIALS AND METHODS F98 glioma-bearing Fischer 344 rats were injected intravenously with Evans blue with or without blood-tumor barrier disrupt...

Correspondence : Mikio MIYATA at the above address. was given 2 days before the challenge, with variousconcentrationsbeingtested. Chloroform as trihalomethane in drinking water was administered for 2 days before the challenge. pDichlorobenzene was inhaled at one of several concentrations for 2 days before the challenge. The animals were sacrificed 30 min after the challenge by exsanguination un...