1. Bonnet R. Growing group of extended-spectrum b-lactamases: the CTX-M enzymes. Antimicrob Agents Chemother 2004; 48: 1–14. 2. Weill FX, Perrier-Gros-Claude JD, Demartin Met al. Characterization of extended-spectrum-b-lactamase (CTX-M-15)-producing strains of Salmonella enterica isolated in France and Senegal. FEMS Microbiol Lett 2004; 238: 353–8. 3. Bouallègue-Godet O, Ben Salem Y, Fabre L et...

Although resistance to the expanded-spectrum cephalosporins among members of the family Enterobacteriaceae lacking inducible b-lactamases occurs virtually worldwide, little is known about this problem among isolates recovered in South Africa. Isolates of Klebsiella pneumoniae, Escherichia coli, and Proteus mirabilis resistant to expanded-spectrum cephalosporins recovered from patients in variou...

objective(s) resistance to the new generation of cephalosporins which is mediated by extended-spectrum beta-lactamases (esbls) has been found among escherichia coli isolates throughout the world. these resistance genes and their producers, the micro-organisms carrying beta-lactamases, are responsible for serious clinical and therapeutic problems among inpatients and it is necessary to pay more ...

abstract background: pseudomonas aeruginosa is one of the most common gram negative bacteria involved in nosocomial infections. presence of extended-spectrum beta-lactamases (esbls) genes, play an important role in induction of resistance in beta-lactamase producing species to beta lactam antibiotics. frequency of resistance to these antibiotics is increasing. in this study, antibiotic sensitiv...

conclusions the levels of resistance to ceftazidime were remarkably variable among ctx-mproducers. this study provides further evidences of the global dissemination of ctx-m type esbls and emphasized on the need for their epidemiological monitoring. results in phenotypic confirmatory test, 154 (44%) out of 350 clinical isolates were esbl positive. using molecular assay, 154 strains potentially ...

background: resistance to contemporary broad-spectrum b-lactam antibiotics mediated by extended-spectrum b-lactamases (esbls) is increasing worldwide. klebsiella pneumoniae , an important cause of nosocomial and community acquired urinary tract infections has rapidly become the most common esbl producing organism. we examined esbl production in urinary isolates of k. pneumoniae in relation to t...

Beta-lactamase enzymes (BLs) have become the most worrisome mediators of antimicrobial resistance expressed by gram-negative bacteria (GNB). The multiple families of BLs have in common the ability to hydrolyze the -lactam rings of one or more members of the penicillins, cephalosporins, cephamycins, carbapenems, and monobactams. Extended-spectrum -lactamases (ESBLs) are a subset of BLs that conf...