We report the case of a 55-year-old Japanese patient with granuloma faciale (GF) successfully treated with topical tacrolimus and describe the immunohistochemical study. Immunohistochemical staining revealed that the patient's granuloma contained CD3(+), CD4(+), CD8(+), CD68(+) and CD163(+) cells. Interestingly, these cells contained granulysin(+) T cells and lacked Foxp3(high+) regulatory T ce...

Granuloma faciale is a rare dermatosis of chronic course, benign, usually asymptomatic, first described in 1945 by Wingley. It is characterized by the appearance of well-defined, single or multiple papules, plaques and nodules, predominantly located in sun-exposed areas, especially the face. In this work we report the case of a female patient, 58 years old, evolving for ten years with multiple ...

introduction: granuloma faciale is an uncommon inflammatory dermatosis which usually affects the face and is often resistant to treatment. case report: a 39-year-old english lady with fitzpatrick skin phototype ii presented with typical lesions of granuloma faciale, confirmed on biopsy, on her cheeks and nose. treatment with scleroplus pulsed dye laser (candela corporation, wayland, mass) produ...

Granuloma faciale (GF) is a rare benign chronic inflammatory dermatosis often difficult to distinguish clinically from other diseases, both and neoplastic. Dermoscopy can be helpful diagnostic tool indeed several dermoscopic criteria observed in GF have been described literature. We present two patients affected by which we rosettes.

A 41-year-old white man with a long history of acne rosacea was referred for evaluation of a persistent erythematous lesion on his nose. The lesion had been present for 2 years and had proved resistant to topical and oral antibiotic therapy. Examination of the patient’s face revealed malar erythema, scattered acnei form papules , and an absence of comedones, consistent with mild acne rosacea. O...

Granuloma faciale (GF) is a rare skin disorder with a chronic-relapsing course. Cutaneous lesions affect predominantly the face of middle-aged Caucasian men with characteristic reddish papules, nodules, or plaques; however, various atypical cases with unusual morphology or extra facial involvement have been reported (1-3). Despite many treatment options, both surgical and medical, GF remains th...