Acamprosate reduces the craving for alcohol by decreasing glutamate activity and increasing gamma-aminobutyric acid (GABA) action in patients with alcohol dependence. Acamprosate has tolerable side effects that include diarrhea, headache, dizziness and pruritus. In this study, we report acamprosate-induced extrapyramidal symptoms in an elderly patient with no history of neurologic disease. Seve...

After introduction of the phenothiazines in the therapy of psychoses it was soon evident that these compounds produce a series of so-called extrapyramidal symptoms (Labhardt, 1954) besides the anti-psychotic effect. It has been much discussed whether the extrapyramidal symptoms are a necessary condition for obtaining anti-psychotic effect (Fliigel, 1956) or an inevitable consequence of the trea...

Results Therewere significant differencesbetweenthe premorbid groups on change onthe Positive and Negative Syndrome Scale,Clinical Global Impression severity and cognitive functioningand Extrapyramidal Symptoms Rating Scale.Patients inthe ‘stable^good’premorbid group (n1⁄4251) improvedmore thanthose in the‘stable^ poor’ (n1⁄4198) and‘declining’ (n1⁄481) groups.The‘stable^good’group received the...

selective estrogen receptor modulators (serms) such as raloxifene have already shown beneficial effects on negative, positive and general psychopathology symptoms in postmenopausal women with schizophrenia. the purpose of the present investigation was to assess the efficacy of raloxifene as an adjuvant agent in the treatment of men with chronic schizophrenia in an 8-week double-blind and placeb...

BACKGROUND We present the case of a 52-year-old woman with depression who developed extrapyramidal symptoms (mainly parkinsonism) and suicidal ideation while on fluoxetine. METHODS The patient underwent neurological and neuroimaging examination. RESULTS The patient's neurological and neuroimaging examinations were normal and there was no other cause of extrapyramidal symptoms. The patient s...

This case report describes the induction of extrapyramidal symptoms with fluoxetine, which is reported to be a rare phenomenon. A dopamine blockade at the nigrostriatal level primarily mediated by serotonin has been proposed as the probable mechanism.