PURPOSE The study looked into the feasibility of producing pellet using Avicel CL611 as spheronization aid by the extrusion/spheronization technique. METHODS Pellets were formulated to contain either 20% or 40% Avicel CL611 and lactose monohydrate as the other sole ingredient. Water is used as liquid binder. Quality of pellets and extrudates were analyzed for size distribution, shape, surface...

In present times, the pelletization technologies are giving much attention as they represent an efficient pathway for manufacture of new drug delivery system .It has good advantage over the conventional dosage form. Pelletization technique help in the formation of spherical beads or pellets having a diameter 0.5 -1.5 mm which can be eventually coated for preparation of modified release dosage f...

The present study aims at discussing the potential advantages of multiple unit dosage forms (pellets etc.) over the single unit dosage forms (tablets). Pelletization is a novel drug delivery system; a technique which converts fine powder particles into pellets. Review deals with the pellet and its various types of pelletization techniques like spheronization and extrusion, pelletization by laye...

Multiparticulate systems (pellets) of prasugrel hydrochloride were prepared by extrusion spheronization method using MCC (micro crystalline cellulose). Optimum spheronization time and method of drying were selected as the process parameters for the preparation of final batches. Various pellet properties were evaluated like size & shape analysis, flow properties, bulk & tapped density, friabilit...

objective(s) the aim of this study was to investigate the possibility of production of ibuprofen pellets with high amount of rate retarding polymer by aid of peg400 as plasticizer. materials and methods polyethylene glycol (peg400) in concentrations of 1, 3 or 5% w/w with respect to eudragit rl was used in production of pellets containing 60% ibuprofen and 40% excipient (2% polyvinylpyrrolidone...

The review focused on technique of solid self-emulsifying pellets (SEPs) for solubility enhancement poorly water soluble drug. oral route administration has been and still is currently the primary drug delivery owing to its potential advantages compared other routes. process hydrophobic drugs plays a key role in formulation development achieve bioavailability therapeutic action at target site.1...

sion/spheronization affects the properties of the resulting pellets. Pharmaceutical scientists originally directed their focus to extrusion, spheronization and drying which can be seen from the literature. Only a few authors reported investigations concerning the impact of the granulation step. Baert et al. investigated ternary mixtures of microcrystalline cellulose (MCC), a drug substitute and...

Doxazosin mesylate (DXM) sustained release pellets were prepared by an extrusion-spheronization and fluid-bed coating technique. The core pellets containing DXM were prepared by extrusion-spheronization technique, and coated by a fluid-bed coater to control the release of DXM. The factors affecting to properties of pellets, such as diluent content, type and coating level of coating agents and p...

OBJECTIVES This study evaluates the effect of substitution of microcrystalline cellulose (MCC) with ethylcellulose (EC) on mechanical and release characteristics of theophylline pellets. MATERIALS AND METHODS The effect of addition of EC was investigated on characteristics of pellets with varying drug content prepared by extrusion-spheronization. Also the effect of type of granulating liquid ...