Bioactive oxidized linoleic acid metabolites (OXLAMs) include 13- and 9-hydroxy-octadecadienoic acid (13-HODE + 9-HODE) and have been linked to oxidative stress, inflammation, and numerous pathological and physiological states. The purpose of this study was to measure changes in plasma 13-HODE + 9-HODE following a 75-km cycling bout and identify potential linkages to linoleate metabolism and es...

Oxidative stress is believed to be one of the major factors behind several acute and chronic diseases, and may also be associated with ageing. Excess formation of free radicals in miscellaneous body environment may originate from endogenous response to cell injury, but also from exposure to a number of exogenous toxins. When the antioxidant defence system is overwhelmed, this leads to cell dama...

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Over the last 20 years, overwhelming evidence has accumulated indicating that oxidation of lipoproteins plays an important role in the development of atherosclerosis (1 ). The pathophysiology of atherosclerosis is characterized by two key processes, lipid deposition and inflammation, within the arterial wall, and oxidative stress provides a link between the two (2 ). Despite general acceptance ...

BACKGROUND F2 -isoprostanes, a biomarker of oxidant injury, increase with advancing chronic kidney disease (CKD) in humans. In cats, the relationship between CKD and oxidative stress is poorly understood. OBJECTIVES To determine whether cats with advancing CKD have increasing urinary F2 -isoprostanes. ANIMALS Control cats without evidence of CKD (≥6 years old; n = 11), and cats with IRIS st...

products of lipid peroxidation (F2-isoprostanes) in smokers. Smoking as a cause of oxidative damage. N Engl J Med 1995; 332: 1198–1203 2. Handelman GJ, Walter MF, Adhikarla R et al. Elevated plasma F2-isoprostanes in patients on long-term hemodialysis. Kidney Int 2001; 59: 1960–1966 3. Patrono C, FitzGerald GA. Isoprostanes: potential markers of oxidant stress in atherothrombotic disease. Arter...