INTRODUCTION Classically, the monocytic component of acute myelomonocytic (FAB-M4) and acute monocytic/monoblastic (FAB-M5) leukemias is demonstrated by nonspecific esterase positivity in cytochemical stainings. We have previously demonstrated that non-specific esterases from normal monocytes can be determined by a chemiluminescent method. In the present study, we investigated whether this assa...

Classification The FAB and WHO classifications The French-American-British (FAB) cooperative group produced the first systematic attempt of a classification dividing myelodysplastic syndrome (MDS) into five subgroups: refractory anemia (RA), RA with ringed sideroblasts (RARS), RA with excess of blasts (RAEB), RAEB in transformation (RAEB-t), and chronic myelomonocytic leukemia (CMML)1;2. Distin...

The World Health Organization (WHO) classifies acute myeloid leukemia (AML) via genetic, immunophenotypic, biological, and clinical features. Still, "AML, not otherwise specified (NOS)" is further subdivided based on morphologic criteria similar to those of the French-American-British (FAB) classification. We analyzed the relevance of this practice in patients with newly diagnosed "AML, NOS" wi...

In this paper the problem of 3D scene and object classification from depth data is addressed. In contrast to high-dimensional feature-based representation, the depth data is described in a low dimensional space. In order to remedy the curse of dimensionality problem, the depth data is described by a sparse model over a learned dictionary. Exploiting the algorithmic information theory, a new def...

Atomic bomb/Leukemia/Threshold/FAB classification/Chromosome Characteristic features of leukemia among atomic bomb survivors were studied. The ratio of a single leukemia type to all leukemias was highest for CML in Hiroshima, and the occurrence of CML was thought to be most characteristic for atomic bomb radiation induced leukemia. In the distribution of AML subtypes of FAB classification, ther...

This issue of Cancer Control focuses on the clinicopathologic features of chronic T-cell leukemia/ lymphoma. Chronic leukemia of T-cell origin was first identified by Brouet and colleagues in 1975. Several classification systems for T-cell lymphoid malignancies have been proposed since then. The French-American-British (FAB) Cooperative Group’s proposal for classification designated four subgro...

PURPOSE French-American-British (FAB) classification of acute leukemia with genetic heterogeneity is important for treatment and prognosis. However, the distinct protein profiles that contribute to the subtypes and facilitate molecular definition of acute leukemia classification are still unclear. EXPERIMENTAL DESIGN The proteins of leukemic cells from 61 cases of acute leukemia characterized...

Several reports indicate that there might be differences in clinical features between Asian and Western myelodysplastic syndrome (MDS) cases. We analyzed refractory anemia (RA) in French-American-British (FAB) classification cases diagnosed in Japan and Germany to perform a more exact comparison between Asian and Western MDS types. In the first step, we analyzed agreement of morphologic diagnos...

A useful classification of acute leukemia must be reproducible, must impart understanding of leukemogenesis and clinical behavior, and (most importantly) be clinically relevant, which makes such a classification indispensable for designing and comparing clinical trials. Classification systems by their very nature may influence the design of treatment regimens and may even bias investigations of...