BACKGROUND The Frontal Assessment Battery (FAB) has been shown to be useful in evaluating frontal dysfunction. There is a paucity of studies validating cutoffs in the early cognitive impairment. We aim to validate the Chinese FAB in Asian subjects with mild cognitive impairment (MCI) and early dementia. METHODS Eighty subjects with MCI and mild dementia and 100 cognitively healthy community s...

BACKGROUND AND OBJECTIVES We studied the function of both Pgp and MRP1 to identify subgroups of patients who could benefit from Pgp reversion, and to clarify in different FAB subtypes and in cytogenetic risk groups their expression and function. DESIGN AND METHODS We examined 132 adults with de novo acute myeloid leukemia (AML) for Pgp and MRP1 expression and function. We correlated our findi...

Acute myeloid leukemia (AML) is a heterogeneous disease with respect to biology and clinical course. Until now the basis for prognostic evaluation and therapeutic decision has been the karyotype, genetic FLT3 abnormalities and the initial chemotherapy response. A question that has emerged is if extensive gene expression analysis may supplement or partly replace current diagnostics. In an attemp...

Osteosarcoma is the commonest type of primary malignant bone tumor, frequently found in adolescents at sites of rapid bone growth. Despite current management protocols, up to half of the patients succumb to this disease. Moreover, there is no well-characterized molecular marker for diagnosis and prognosis. Since phage display methodology allows the selection of human antibody fragments with pot...

Let G be a profinite group. We denote by rn(G) the number of isomorphism classes of irreducible n-dimensional complex continuous representations of G (so that the kernel is open in G). Following [20], we call rn(G) the representation growth function of G. If G is a finitely generated profinite group, then rn(G) < ∞ for every n if and only if G has the property FAb (that is, H/[H,H] is finite fo...

The purpose of a classification is not only to group diseases with the same biological characteristics, but also to get insight into the pathogenesis and to define subgroups with different prognoses and different therapeutic approaches. In acute leukaemias the classification now most widely used is the French-American-British (FAB) classification as proposed in 1976, which was based on morpholo...

Acute myeloid leukemia (AML) should be classified into subtypes according to the French-American-British (FAB) or, preferably, the newer World Health Organization (WHO) classification schemes. FAB is purely a morphological classification. It does not determine treatment (except M3) or prognosis for the patient which requires cytogenetics. Haematological analyzer had been used for classification...

In a study of 56 consecutive adult patients with de novo myelodysplastic syndromes (MDS), all cases were successfully analyzed with two refined chromosome banding techniques. Most patients (44 of 56, 79%) were found to have a chromosome defect. The majority of these patients had a recurrent loss of chromosomal material rather than a reciprocal translocation or inversion, as commonly found in ac...

Let G be a finite group and U ( Z ) ${\mathcal {U}}({\mathbb {Z}}G)$ the unit of integral ring ${\mathbb {Z}}G$ . We prove theorem, namely, characterization when $\mathcal {U}(\mathbb {Z}G)$ satisfies Kazhdan's property T $(\operatorname{T})$ , both in terms simple components semisimple algebra Q $\mathbb {Q}G$ Furthermore, it is shown that for {Z} G)$ this equivalent to weaker FAb $\operatorna...