Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, Plasmodium malariae, and Plasmodium knowlesi are the parasites that infect humans. Plasmodium falciparum and Plasmodium vivax cause most of the malarial infections worldwide. Plasmodium vivax, Plasmodium ovale, Plasmodium malariae, and Plasmodium knowlesi are susceptible to chloroquine. Chloroquine was the world's most widely used antim...

background: molecules expressed on the surface of infected erythrocytes (ie) with plasmodium falci-parum play important roles in malaria pathogenesis and immune evasion. some of these molecules are specific adhesive ligands mediating adhesion of ie to the vascular endothelium. in the current study, the antigens exposed on the surface of ie with different isolates and various binding subpopulati...

background: cytoadherence of plasmodium falciparum - infected erythrocytes to host cells is an im-portant trait for parasite survival and has a major role in pathology of malaria disease. infections with p. falciparum usually consist of several subpopulations of parasites with different adhesive prop-erties. this study aimed to compare relative sizes of various binding subpopulations of differe...

Fourteen plant species collected in Iran and selected mainly on the basis of their antimicrobial and/or antifungal activities were evaluated for in vitro antiplasmodial and cytotoxic effects in a study designed to screen plant extracts with selective activity against Plasmodium falciparum. The methanol extracts of nine of the species tested exhibit activity against Plasmodium falciparum (MIC va...

background: sickle cell disease (hbss) is a major health problem in nigeria and ma-laria has been implicated as a leading cause of morbidity/mortality in sickle cell disease patients. few reasons were put forward to explain the observed morbidity/mortality of hbss subjects due to plasmodium falciparum (p. falciparum) malaria. objectives: to determine the level of immunoglobulin classes (igm, ig...

background: parasite lactate dehydrogenase ( p ldh) is extensively employed as malaria rapid diagnostic tests (rdts). moreover, it is a well-known drug target candidate. however, the genetic diversity of this gene might influence perfor­mance of rdt kits and its drug target candidacy. this study aimed to determine polymorphism of p ldh gene from iranian isolates of p. vivax and p. falciparum. m...

Plasmodium falciparum malaria remains a disease of significant public health impact today. With the risk emerging artemisinin resistance stalling control efforts, need to deepen our understanding parasite's biology is dire. Extracellular vesicles (EVs) are vital P. and play role in pathogenesis malaria. Recent studies have also shown that EVs may development falciparum. Here, we highlight evide...

Fourteen plant species collected in Iran and selected mainly on the basis of their antimicrobial and/or antifungal activities were evaluated for in vitro antiplasmodial and cytotoxic effects in a study designed to screen plant extracts with selective activity against Plasmodium falciparum. The methanol extracts of nine of the species tested exhibit activity against Plasmodium falciparum (MIC va...