OBJECTIVE Potential moderator and mediator roles of several measures of socioeconomic status (SES) were investigated for the relationship between a family history of alcoholism (FH) and alcohol dependence symptoms in adulthood. METHOD These analyses were performed with a sample of 931 men and 385 women participating in studies at the Alcohol Research Center, University of Michigan. Hierarchic...

Although a slightly elevated office blood pressure (BP) has been reported in several studies, little is known about the prolonged resting blood pressure, heart rate (HR) and baroreflex sensitivity (BRS) of prehypertensive subjects with a family history of hypertension. Office blood pressure, prolonged resting (1 h) BP and HR were measured in 25 young normotensives with a positive family history...

OBJECTIVE A positive family history (FH) is a risk factor for late-onset Alzheimer's disease (AD). Our aim was to examine the effects of FH on pathological and neuronal loss biomarkers across the cognitive spectrum. DESIGN Cross-sectional analyses of data from a national biomarker study. SETTING The Alzheimer's Disease Neuroimaging Initiative national study. PATIENTS 257 subjects (ages 55...

Knowledge of association between breast cancer and risk factors family history can help change the health behaviour. To reduce associated with among young women in Saudi Arabia, it is necessary to understand degree perception socio-economic differences. A cross-sectional study 253 aged 25-64 years investigated awareness (positive history) for cancer. Standard self-administered questionnaire, sc...

Greaney JL, Matthews EL, Wenner MM. Sympathetic reactivity in young women with a family history of hypertension. Am J Physiol Heart Circ Physiol 308: H816–H822, 2015. First published February 13, 2015; doi:10.1152/ajpheart.00867.2014.—Young adults with a family history of hypertension ( FH) have increased risk of developing hypertension. Furthermore, the blood pressure (BP) response to sympatho...

We have previously described a subset of subjects with essential hypertension who fail to appropriately modulate renal vascular and adrenal reactivity with changes in dietary sodium and in response to infused angiotensin II (Ang II). In this paper, we studied these responses in 13 unselected hypertensive subjects in whom the family history of hypertension had been carefully detailed. Nine of th...

Neuroimaging studies of individuals with family histories of alcoholism provide evidence suggesting neurobiological risk factors for alcoholism. Youth family history positive (FH+) for alcoholism exhibit increased impulsivity compared to family history negative (FH-) peers in conjunction with altered functional activation in prefrontal cortex, including anterior cingulate cortex (ACC). This stu...

aim : the present study aimed to evaluate the prevalence of positive family history of these cancers in a large population-based sample of tehran province, capital of iran. background : upper gastrointestinal (ugi) cancers (gastric and esophagus cancer) constitute a major health problem worldwide. a family history of cancer can increase the risk for developing cancer and recognized as one of th...

BACKGROUND Abstinent alcoholics have deficits in comprehending the affective intonation in speech. Prior work suggests that these deficits are due to alcohol exposure rather than preexisting risk factors for alcoholism. The present paper examines whether family history of alcoholism is a contributor to affective prosody deficits in alcoholics. METHODS Fifty-eight healthy, nonabusing young adu...

BACKGROUND Abnormalities in baroreflex control of heart rate may be important in the pathogenesis of essential hypertension. METHODS AND RESULTS To investigate the influence of heredity on baroreflex function, we measured baroreflex sensitivity in 40 untreated patients with essential hypertension grouped by the presence (FH+) or absence (FH-) of a family history of hypertension and in 24 norm...