In recent days the use of fast mouth dissolving tablets are well accepted by elderly, children and the patients having trouble in swallowing and even by the travelling patients who find it convenient to ingest. Cinnarizine is a piperazine derivative and is widely prescribed for the treatment of vestibular disorders and motion sickness. To enhance the anti-emetic and anti-migraine properties of ...

Recently, fast-dissolving drug delivery systems have started gaining popularity and acceptance as new drug delivery systems, because they are easy to administer and lead to better patient compliance. Usually, elderly people experience difficulty in swallowing the conventional dosage forms (tablets, capsules, solutions and suspensions) because of tremors of extremities and dysphasia. Fast-dissol...

lamotrigine is used in the treatment of cns disorders, particularly epilepsy; pain; oedema; multiple sclerosis and psychiatric indications including bipolar disorder. lamotrigine belongs to biopharmaceutical classification systems, bcs class ii (low solubility & high permeability). in addition, it requires immediate therapeutic action hence the main objective of this study is to improve the sol...

This study was concerned with the investigation of acute pharmacological responses (pharmacodynamics) including analgesic and anti-inflammatory effects of ketorolac tromethamine fast dissolving tablets prepared by direct compression method using 3% croscarmellose sodium as a superdisintegrant by applying tail flick test and carragenan induced rat paw edema test respectively. Also, the work aime...

Amlodipine besylate is a long‐acting calcium channel blocker used to treat chronic stable angina, vasospastic angina and hypertension. Amlodipine is a sparingly soluble orally administered drug and the rate of absorption is often controlled by the rate of dissolution. The rate of dissolution will increase by incorporating the drug in a fast dissolving dosage form. An attempt will be made to dev...

In the present work, Flunarizine hydrochloride, an anti-migraine drug has been formulated into fast dissolving tablets by sublimation method using camphor and menthol as sublimating agents and treated agar as superdisintegrant. Concentrations of the sublimating agents were varied keeping the concentration of superdisintegrant fixed. The aim of the study was to prepare fast dissolving tablets wi...

Submitted 2011.09.28. Accepted for publication 2011.12.19. The convenience of administration and improved patient compliance are important in the design of oral drug delivery system which remains the preferred route of drug delivery inspite of various disadvantages. One such problem can be solved in the novel drug delivery system by formulating “mouth dissolving tablets” (MDTs) which disintegra...