the newborn who is born before terms is a candidate for the development of idiopathic respiratory distress syndrome. the intense hypoxia and acidosis that ensue as the consequence of inadequate alveolar-capillary exchange of oxygen and carbon dioxid may prove fatal antenatal steroid therapy can affect rds (respiratory distress syndrom) and its complications. the newborn before 34 weeks have a s...

objective(s):hypoxia induces cellular oxidative stress that is associated with neurodegenerative diseases. here, the protective effects of ferulic acid (fa) on hypoxia-induced neurotoxicity in pc12 cells were evaluated. materials and methods:we investigated the effect of fa on pc12 cells subjected to hypoxia stress, in vitro. results:fa increased cell viability, prevented membrane damage (ldh r...

The most common pediatric mitochondrial disease is Leigh syndrome, an episodic, subacute neurodegeneration that can lead to death within the first few years of life, for which there are no proven general therapies. Mice lacking the complex I subunit, Ndufs4, develop a fatal progressive encephalopathy resembling Leigh syndrome and die at ≈60 d of age. We previously reported that continuously bre...

Local recurrence and distant metastasis frequently occur after radiation therapy for cancer and can be fatal. Evidence obtained from radiochemical and radiobiological studies has revealed these problems to be caused, at least in part, by a tumor-specific microenvironment, hypoxia. Moreover, a transcription factor, hypoxia-inducible factor 1 (HIF-1), was identified as pivotal to hypoxia-mediated...

Gastric perforation in neonates is a rare but frequently fatal condition of uncertain etiology. It usually occurs in infants requiring resuscitation or having an episode of hypoxia following birth (1). Although massive pneumoperitoneum is a consistent radiographic characteristic in most of the cases, a few reports have highlighted unusual imaging findings in neonatal gastric perforation (2). He...

*Supported in part by the Mr. and Mrs. F. H. Tewksbury grant administered by the San Diego Bio-Chemical Research Institute. 3-13-64 electrocardiographic changes in antigenantibody reactions have been described.34 Electrocardiographic observations of near fatal anaphylactic reactions in the human are sparse. In anaphylactic shock, the most dread of all allergic manifestations, widespread histami...

Two cases of fatal lightning injury are described. Fixed dilated pupils should not be taken as an indicator of death after a lightning strike. Persons who fail to breath spontaneously within one minute of lightning shock should receive external cardiac massage and mouth-to-mouth resuscitation. Paralysis may persist as result of cerebral oedema or prolonged hypoxia-it is therefore suggested that...

Pulmonary tumor thrombotic microangiopathy (PTTM) is a fatal malignancy-related condition that involves rapidly progressing hypoxia and pulmonary hypertension. We report a case of PTTM caused by prostate carcinoma, which was diagnosed before autopsy in an 81-year-old man. Computed tomography showed diffuse ground-glass opacities, consolidation, and small nodules in the peripheral regions of the...