Background: Neonatal sepsis is a life-threatening disease with an incidence of 1 to 10 per 1000 live births and a mortality rate of 15% to 50%. The clinical signs are non-specific and indistinguishable from those caused by a variety of neonatal noninfectious disorders. Objective: The aim of this study was to determine the importance of CD64 expression (FcgRI), a neutrophil surface marker, in ea...

OBJECTIVE In inflammatory diseases, differentiation between infection and disease flares is often clinically difficult because of similar signs and symptoms, such as fever and elevation of inflammatory markers. In rheumatoid arthritis (RA), infection is not only one of the major complications but also one of the frequent causes of death. Use of biologic agents such as tumor necrosis factor-a bl...

Immunoglobulin G (IgG) is the main serum glycoprotein responsible for detection and destruction of pathogens or their noxious products. IgG consists of Fab (‘fragment antigen binding’) regions, that recognize antigenic targets and provide diversity to antibodies, and Fc (‘fragment crystallizable’) regions, that allow antibodies to interact with Fc gamma receptors (FcgR) on phagocytes (Fig. 1). ...

Recombinant monoclonal antibodies have entered the clinic as effective in vivo therapeutic. A majority of the therapeutics antibodies employed are intact IgG molecules. IgG-antibody/antigen complexes can activate a wide range of biological responses that result in elimination and destruction of immune complexes. Principle ligands for the activation of clearance (inflammatory) mechanisms are the...

In the important paper of Kuda et al. [1] published in ”Cardiology Journal” it was found that vasospasm-induced coronary flow reduction is a major contributory factor in anaphylactic ventricular dysfunction. The authors concluded that during anaphylaxis the ensuing left ventricular dysfunction is attributed mainly to coronary vasoconstriction-induced myocardial ischemia. These and other experim...

The biochemical signaling mechanisms involved in transducmembrane and cytosolic fractions, but had no effect on IFNg–mediated early AA release suggesting dual mechanism of ing the effects of interferon-g (IFN-g) on human leukemiaderived HL-60 cell differentiation are not completely unPLA2 activation. Melittin, potent activator of PLA2, and AA mimicked the effect of IFN-g on SM hydrolysis. Pretr...

Catumaxomab (CatmAb), a trifunctional bispecific antibody directed against the epithelial cell adhesion molecule (EpCAM) and the T-cell antigen CD3, is approved as intraperitoneal therapy for the treatment of malignant ascites in patients with EpCAM-positive carcinomas. The immunomonitoring results of a phase II/III study using CatmAb revealed a tumoricidal effect associated with reduced VEGF l...