PURPOSE Airway remodeling may be responsible for irreversible airway obstruction in asthma, and a low post-bronchodilator FEV1/FVC ratio can be used as a noninvasive marker of airway remodeling. We investigated correlations between airway wall indices on computed tomography (CT) and various clinical indices, including post-bronchodilator FEV1/FVC ratio, in patients with asthma. METHODS Volume...

To investigate the effects of dietary magnesium, potassium, and sodium on children's lung function, the authors examined cross-sectional dietary data and pulmonary function tests from 2,566 children aged 11-19 years who attended schools in 12 southern California communities during 1998-1999. During school visits, each child completed a health update questionnaire, a validated food frequency que...

STUDY OBJECTIVES To determine the relationship between weight-loss and pulmonary function indexes, focusing on forced expiratory flows (ie, FEV(1), forced expiratory flow at 50% of vital capacity [FEF(50)], forced expiratory flow at 75% of vital capacity, and forced expiratory flow at 25 to 75% of vital capacity [FEF(25--75)]). Specifically, to determine the effect of losses in total and segmen...

STUDY OBJECTIVE The ratio between forced expiratory flow between 25% and 75% of vital capacity (FEF(25-75)) and FVC is thought to reflect dysanapsis between airway size and lung size. A low FEF(25-75)/FVC ratio is associated with airway responsiveness to methacholine in middle-aged and older men. The current study was designed to assess this relationship in both male and female subjects over a ...

BACKGROUND We recently reported that antioxidant supplementation with vitamins C and E mitigated ozone related decline in forced expiratory flow (FEF(25-75)) in 158 asthmatic children in an area with high ozone exposure in Mexico City. METHODS A study was undertaken to determine whether deletion of glutathione S-transferase M1 (GSTM1 null genotype), a gene involved in response to oxidative st...

Vital kapasitenin %25-%75 arasındaki zorlu ekspiratuar akım (FEF%25-75) küçük hava yolu hastalığı (KHH)’nın değerlendirilmesinde kullanılan solunum fonksiyon testi (SFT) parametresidir. Çalışmamızda, göğüs hastalıkları polikliniğine başvuru yapan FEF%25-75 düşüklüğü saptanan hastaların polikliniğe nedenleri, FEF%25-75’in kronik obstrüktif akciğer (KOAH)’ın erken teşhisine katkısı ve risk faktör...

Objective. To observe the effects of tripterygium glycosides tablet (TPT) on swelling degree, arthritis index (AI), pulmonary function, cytokines, the expression of regulatory T cells (Treg), and Foxp3 in rats of adjuvant arthritis. Methods. Rats were averagely divided into normal control (NC) group, model control (MC) group, methotrexate (MTX) group, and tripterygium glycosides tablet (TPT) gr...

This work was intended to evaluate the prevalence of obstructive small-airway disease in patients with rheumatoid arthritis (RA) and its association with clinical characteristics. Pulmonary function testing (PFT) and high-resolution computed tomography (HRCT) were performed on 189 consecutive RA patients. Each case was diagnosed based on abnormal HRCT findings. We defined obstructive dysfunctio...