Effect of hexane extract of Ferula jaeschkeana has been studied on corpora lutea of adult cyclic guinea-pigs. Administration of extract showed duration dependent luteolytic changes in the corpora lutea. Its administration for first three days from the onset of estrus caused significant decrease in the diameter of corpora lutea in the ovary at day 10 of cycle. Ovarian wet weight, proteins and gl...

dormancy breaking and germination requirements were investigated in seeds of ferula ovina and ferula gummosa. seeds of rather species were collected from north and eastern-north rangelands of iran. seeds of each of the species were subjected to different treatments including various levels of ga3, chilling and combination of ga3 and chilling (ga-chilling). in contrast to treated seeds, non-trea...

Dormancy breaking and germination requirements were investigated in seeds of Ferula ovina and Ferula gummosa. Seeds of rather species were collected from north and eastern-north rangelands of Iran. Seeds of each of the species were subjected to different treatments including various levels of GA3, chilling and combination of GA3 and chilling (GA-chilling). In contrast to treated seeds, non-trea...

Neuroinflammation mediated by microglia cells plays a critical role in the development of Alzheimer's disease. To identify novel natural neuroinflammation inhibitors, a bioactivity-guided phytochemical research was performed on the traditional Chinese medicine "Awei", that exhibited a significant inhibitory effect on nitric oxide production in over-activated microglia cells. The research identi...

Methanolic extract of 15 Iranian medicinal plants were prepared and tested for their cytotoxic activities against three cancer cell lines (MCF7, HepG2, WEHI164) and one normal cell line (MDBK). Some plants showed cytotoxic activities. The extract of Ferula szowitsiana root, which proved to be the most active, was chosen for further phytochemical studies. The major compounds of the most potent a...

Xinjiang, a region of high salinity and drought, is a host to many arid and semi-arid plants. Many of these plants including Ferula spp. have indigenous pharmaceutical histories. As many of the medicinal properties of plants are in tandem with the associated microorganisms residing within the plant tissues, it is advisable to explore the endophytic potential of such plants. In the present study...