Cytotoxicity of depleted uranium, as a byproduct of military has been came to spotlight in recent decades. DU is known as a chemical rather than radioactive hazard and efforts to illustrating its mechanism is undergo, but the precise complete molecular mechanisms are still unclear. Recent studies showed that uranium induces biological changes in many different target tissues, such as the kid...

abstract ethanol has a vast consumption around the world. many researches confirmed some adverse effect of this component on human health. in addition, recent studies showed significant alteration in both cellular population, and protein profile of human foreskin fibroblast cell line (hfff2) in the specific dosage of ethanol. here, the role and interaction of some proteins (characterized by sig...

Objective(s): Umbilical cord blood is a good source of the mesenchymal stem cells that can be banked, expanded and used in regenerative medicine.  The objective of this study was to test whether amniotic membrane extract, as a rich source of growth factors such as basic-fibroblast growth factor, can promote the proliferation potential of the umbilical cord mesenchymal stem cells. Materials and ...

cytotoxicity of depleted uranium, as a byproduct of military has been came to spotlight in recent decades. du is known as a chemical rather than radioactive hazard and efforts to illustrating its mechanism is undergo, but the precise complete molecular mechanisms are still unclear. recent studies showed that uranium induces biological changes in many different target tissues, such as the kidney...

human diploid fibroblast cells produce a spectrum of necessary growth factors and extracellular matrix (ecm) components essential for growth and proliferation of a variety of other cell types. in this study, the effect of five human embryonic fibroblast cell lines, isolated from liver, lung, skin and foreskin tissues, was investigated. a coculture system analyse was employed to cloning efficien...

Background: Fibroblast cell lines have different application in biological research including nuclear transfer in cloning, feeder layer of embryonic stem cells, wound healing research and tissue engineering. The objective of the present study was to determine the proper pregnancy age for collecting and culturing guinea pig fetal fibroblast. Materials and Methods: Guinea pig fetuses were collect...

Recently, there has been a great interest in melanoma and stromal cell-to-cell interactions behind the progressive behavior of melanoma. By vitro co-culturing using sequential seeding conditions imitating niche properties, gained hybrid variants are visualized by high content fluorescent microscopy. The co-culture experiment applied consecutive order primarily plated HDF-RFP-ZeoR fibroblast mon...

background: camellia sinensis and zataria multiflora as the potent antioxidants and anti-inflammations are crucial in the management of wound therapy. lipopolysaccharide (lps) was used for the proliferative potential on fibroblast cells and induction of inflammatory mediators. objective: we examined the effects of lps and herbal extracts combination in order to identify their mechanisms of acti...

Previous studies indicate that organ fibroblasts play an important role in wound healing, collagen production, remodeling processes and pathogenesis of progressive heart, lung, renal and hepatic fibrotic diseases. Several studies suggest a possible inhibitory role for adenosine in the regulation of fibroblast proliferation. The effect of adenosine A2 agonists on proliferation and differentiatio...