OBJECTIVE To investigate the effect of fibroids on fertility and of myomectomy in improving outcomes. DESIGN Systematic literature review and meta-analysis of existing controlled studies. SETTING Private center for Reproductive endocrinology and infertility. PATIENT(S) Women with fibroids and infertility. INTERVENTION(S) A systematic literature review, raw data extraction and data analy...

OBJECTIVES Fibroids are common, hormone-dependent, benign uterine tumors. They can cause significant morbidity and the symptoms depend largely on their size. The aim of this study was to describe the natural history of fibroids and identify factors that may influence their growth. METHODS This was a retrospective longitudinal study of premenopausal women who were diagnosed with uterine fibroi...

Uterine fibroids are benign monoclonal neoplasms of the myometrium, representing most common tumors in women worldwide. To date, no long-term or noninvasive treatment option exists for hormone-dependent uterine fibroids, due to limited knowledge about molecular mechanisms underlying initiation and development fibroids.

Mediator complex subunit 12 (MED12) is a part of the mediator complex, which is believed to regulate transcription. MED12 is mutated at high frequency and with different mutation frequencies in uterine fibroids and breast fibroadenomas of different populations. This study aimed to analyze MED12 mutations in Senegalese population. MED12 was sequenced in the tumoral tissues and blood samples of S...

This study aimed to compare vascular parameters between fibroid and myometrium. From 10 uteri, specimens were taken from small fibroids (<0.5 cm), from the inner and outer parts of large fibroids (>3 cm), and from myometrium. Antibodies to endothelial cell markers CD31, CD34, factor VIII-related antigen (FVIII), and Ulex europaeus lectin were used in routine immuno- and lectin chemistry protoco...

Overview: Uterine leiomyomas (fibroids or myomas) are benign tumors. Since histologic confirmation of the clinical diagnosis is not necessary in most cases, and there is both growth and regression of fibroids, asymptomatic uterine leiomyomas can usually be followed without intervention. Research supports not treating asymptomatic fibroids. Treatments for symptomatic fibroids include medical man...

OBJECTIVE To investigate the impact of fibroids on the blood flow of the uterine and subendometrial arteries and in vitro fertilization (IVF) outcomes. METHODS In this study, we analyzed 86 IVF/intracytoplasmic sperm injection (ICSI) cycles in which a gonadotropin-releasing hormone antagonist protocol was used for controlled ovarian stimulation between January 2008 and March 2009. The subject...

518 JCOM September 2006 Vol. 13, No. 9 www.turner-white.com Uterine fibroids are the most common tumors of the female reproductive tract. These benign tumors occur in approximately 20% to 25% of women of childbearing age, with increased prevalence rates of over 50% among African-American women [1]. Fibroids may vary in size, from microscopic to larger than a basketball, with many women having m...

Several epidemiological studies have demonstrated the relationship between the existence of fibroids and the occurrence of infertility; indeed fibroids have been reported in 25-30% of infertile women and are responsible for them alone to 2 to 3% of infertility cases when no other cause was found. The objective of this study was to investigate the probable association between the presence of a f...

background:   uterine myomas are common pelvic masses during pregnancy. the pain and rapid growth of myomas are among the most common complications during pregnancy. we evaluate management of painful cystic degeneration of myomas during pregnancy case: a 27-year-old primigravida had a pelvic mass. we have managed a case in which the diagnosis of cystic degeneration of uterine myomas could not b...