Relative to non-drinkers, a low to moderate alcohol intake is associated with lower risk of cardiovascular and total mortality. Epidemiological studies also suggest that a low to moderate red wine consumption may protect against cardiovascular disease. Because epidemiological studies show a similar relationship for different types of alcoholic beverages, the alcohol (ethanol), at low to moderat...

kingdom, is believed to play a preventive role in the development of certain diseases associated with free radical-induced damage in the body. The high sensitivity of flavonoids to react with free radicals makes them pharmacological effective. Flavonoids and their ability to inactivate superoxide anion radicals (O2· ) have been studied for about a decade. Flavonoids are most likely to react wit...

Numerous studies have documented that in cancer therapy flavonoids extracted from traditional Chinese medicine have anti-tumor activity or can enhance efficiency of chemotherapy in combination with chemotherapeutics. Thus, an awareness of flavonoids is needed by physicians and medical researchers. This review provides evidence about anti-hepatocellular carcinoma activity of flavonoids. First, a...

background: although several studies have investigated the association between ovarian cancer risk and nonisoflavone flavonoids intake, these findings are inconsistent. this systematic review of published epidemiological studies was conducted to summarize and clarify the evidence on the association between ovarian cancer incidence and nonisoflavone flavonoids intake. materials and methods: pubm...

NAD(+) is important for oxidative metabolism by serving as an electron transporter. Hyperglycemia decreases NAD(+) levels by activation of the polyol pathway and by overactivation of poly(ADP-ribose)-polymerase (PARP). We examined the protective role of three structurally related flavonoids (rutin, quercetin, and flavone) during high glucose conditions in an in vitro model using human umbilical...

Flavonoids have been shown to be cytotoxic to cancer cells. However, the mechanism of cytotoxicity has not been clearly defined. It has previously been reported that HER2/ERBB2, the estrogen receptor, progesterone receptor, and p53 were required for flavonoid induced cytotoxicity in breast cancer cell lines. We have used a panel of breast cancer cell lines, known to contain as well as be defici...

Plant-specialized (or secondary) metabolites represent an important source of high-value chemicals. In order to generate a new production platform for these metabolites, an attempt was made to produce flavonoids in rice seeds. Metabolome analysis of these transgenic rice seeds using liquid chromatography-photodiode array-quadrupole time-of-flight mass spectrometry was performed. A total of 4392...

Plant flavonoids represent an important group of secondary metabolites and around 6500 varieties of flavonoids have been reported so far. These are the polyphenolic compounds that are found in almost all plant species. Extensive biological roles of flavonoids have been reported which include antiviral, anti-hepatotoxic, therapeutic, antibacterial, and other roles in nature. The presence of flav...

Gastric cancer is the most common cancer among men in Korea, and dietary factors are closely associated with gastric cancer risk. We performed a case-control study using 334 cases and 334 matched controls aged 35-75 years. Significant associations were observed in total dietary flavonoids and their subclasses, with the exception of anthocyanidins and isoflavones (OR (95% CI): 0.49 (0.31-0.76), ...