Although the brownish area at the corneal periphery in the region ofDescemet's membrane was first described by Kayser (I902), and Fleischer (I9I2) recognized it as a part of Wilson's disease (hepato-lenticular degeneration), there have been no previous reports in the ophthalmic literature of the United Kingdom of a pathological study of the lesion which is now recognized as a pathognomonic find...

geminovascular activation in cluster headache. Brain 1994; 117:427–434. 23. May A, Bahra A, Buchel C, Frackowiak RSJ, Goadsby PJ. Hypothalamic activation in cluster headache attacks. Lancet 1998;351:275–278. 24. May A, Ashburner J, Buchel C, et al. Correlation between structural and functional changes in brain in an idiopathic headache syndrome. Nat Med 1999;5:836–838. 25. Kudrow L. Response of...

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Wilson's Disease (WD) is a rare, autosomal, recessive, inborn error of the copper metabolism, which is caused by a mutation in the copper-transporting gene, ATP7B. The presentation is usually neurologic or hepatic, which is seen in 40% of the patients. The diagnosis depends primarily on the clinical features, the biochemical parameters and the presence of the Kayser - Fleischer ring. Here, we a...