Interference with microtubule polymerization results in cell cycle arrest leading to cell death. Colchicine is a well-known microtubule polymerization inhibitor which does so by binding to a specific site on tubulin. A set of 3',4'-bis (substituted phenyl)-4'H-spiro[indene-2,5'-isoxazol]-1(3H)-one derivatives with known antiproliferative activities were evaluated for their tubulin binding modes...

Abstract:   Previous research on bracing members show that the ductility of bracing members is compromised due to the buckling phenomena. Therefore, many researchers have tried to use special considerations to increase the fracture life of bracing members. Some of these recommendations such as increasing the slenderness ratio, using lower width to thickness ratio, increasing the out-of-p...

Multi-core system has wide utility in today’s applications due to less power consumption and high performance. Many researchers are aiming at improving the performance of these systems by providing flexible multi-core architecture. Flexibility in the multi-core processors system provides high throughput for uniform parallel applications as well as high performance for more general work. This fl...

interference with microtubule polymerization results in cell cycle arrest leading to cell death. colchicine is a well-known microtubule polymerization inhibitor which does so by binding to a specific site on tubulin. a set of 3',4'-bis (substituted phenyl)-4'h-spiro[indene-2,5'-isoxazol]-1(3h)-one derivatives with known antiproliferative activities were evaluated for their t...

In this paper, natural frequencies of the sandwich plates with soft flexible core and composite face sheets are obtained. Three-Dimensional (3D) finite element method (FEM) is used for constructing and analyzing of the sandwich plates to obtain their natural frequencies. Continuity conditions for transverse shear stresses at the interfaces as well as transverse flexibility and transverse normal...

introduction: tracheobronchial foreign body may often be treated as asthma, chronic bronchitis or etc. especially in patients with no memories of aspiration episodes. case presentation: a 74-year-old woman, suffering from persistent cough, was temporarily misdiagnosed with allergic bronchopulmonary aspergillosis and treated for six months. during this period, computed tomography (ct) findings c...

We investigate the folding transition of a single diblock copolymer consisting of a semiflexible and a flexible block. We obtain a Saturn-shaped core-shell conformation in the folded state, in which the flexible block forms a core and the semiflexible block wraps around it. We demonstrate two distinctive features of the core-shell structures: (i) The kinetics of the folding transition in the co...