objective: leishmaniasis is one of the significant causes of morbidity and mortality in several countries. it is an important problem in endemic areas such as iran. the goal in treatment of leishmaniasis is to reduce the disease period and leave no evidence of any remaining scars or lesions. a derivative of artemisinin is artemether. scientists believe that the strong action of artemether again...

background: myelodysplastic syndrome is a mixed clonal disorder of bone marrow progenitor cells. understanding the pattern of the different lineage-specific, immature, and mature markers in myelodysplastic syndrome will help in setting-up the frame of reference to diagnose. patients and methods: we compared 60 bone marrow samples from 30 newly-diagnosed patients with myelodysplastic syndrome an...

background: although the pathogenesis of diabetes type 1 (t1d) is not fully elucidated. different clusters of lymphocytes such as cd4+ and cd8+ t cells are involved in it. moreover, the mechanism of how stem-cell therapy results in significant therapeutic outcomes in diabetes remains obscure. in the current study, we aimed to analyze lymphocyte subsets in patients with t1d before and after trea...

background: invariant natural killer cells (inkt) are an important immunoregulatory t cell subset. currently several flow cytometry-based approaches exist for the identifi-cation of inkt cells, which rely on using the 6b11 monoclonal antibody or a combina-tion of anti-vα24 and anti-vβ11 antibodies. objective: the aim of this study was to compare the ability of two flow cytometry-based methods f...

background: celiac disease (cd) is a small bowel enteropathy caused by permanent wheat gluten intolerance. one of the earliest signs of the mucosal immune activation in cd is an increase in the intestinal intraepithelial lymphocytes (iiels) count in the small intestinal epithelium. although most of those iiels express ??tcr, cd is characterized by an increase in the gdtcr + iiels. objective: th...

background: human peripheral blood nk cells constitutively express cd56 and cd16 antigens. peripheral blood nk cells seem to be strongly related with decidual nk cells, and may reflect the decidual nk cell functional status. there are varied reports concerning the relationship between nk cell cytotoxicity in women with recurrent spontaneous abortion. objective: to study nk activity in women wit...

dendrostellera lessertii (thymelaeaceae) is a toxic plant that grows in parts of iran. the anti-proliferative properties of its crude methanol extract and one of its active components, 3-hydrogenkwadaphnin (3-hk), have been established using several cancer cell lines. methods: in a further attempt to determine the mode of action, two groups of synchronously growing cells were treated with a sin...

objective(s): gastric cancer is the first and second leading cause of cancer related death in iranian men and women, respectively. gastric cancer management is based on the surgery, radiotherapy and chemotherapy. in the present study, for the first time, the beneficial effect of saffron (crocus sativus l.) aqueous extract (sae) on the 1-methyl-3-nitro-1-nitrosoguanidine (mnng)-induced gastric c...

background: bernard-soulier syndrome is a rare inherited bleeding disease caused by quantitative or qualitative defect of gpib/ix/v, a platelet complex that binds the von willebrand factor. the expression of gpib-ix-v complex can be evaluated by flow cytometry and confirmed by the absence of ristocetin-induced platelet aggregation in platelet-rich plasma. the main aim of the present study was t...