The human promyelocytic leukemia cell line. HL-60. undergoes differentiation in the presence of dimethyl sulfoxide (DMSO). phorbol esters, and other agents. Studies were undertaken to determine whether agents that promote differentiation influence membrane fluidity and to assess whether changes in membrane fluidity occur during the process of differentiation. Cells were grown in the presence of...

Hemolysis of human or chicken erythrocytes by Sendai virus causes a change in the structure of the erythrocyte membrane lipid bilayer that can be detected by spin label electron spin resonance. In the intact erythrocyte, the phosphatidylcholine derivative spin label exists in a more rigid environment than the corresponding phosphatidylethanolamine label. Virus-induced hemolysis tends to abolish...

objective(s): investigation of acute effect on cellular bioenergetics provides the opportunity to characterize the possible adverse effects of drugs more comprehensively. this study aimed to investigate the changes in biochemical and biophysical properties of heart mitochondria induced by captopril and nifedipine antihypertensive treatment. materials and methods: male, 12-week-old wistar rats i...

The application of ultrasonic vibration to the casting process can be realized through mould (die) vibration. However, resonant is always accompanied by a non-uniform distribution at different parts, which may induce complex liquid flow and affect fluidity during filling process. influence on AlSi9Cu3 alloy was studied with gradients. It found that generate two opposite effects fluidity: first,...

Abnormal plasma lipoproteins in patients with liver disease are associated with characteristic changes in erythrocyte membrane lipid composition. The membranes are enriched in cholesterol and phosphatidylcholine and both the cholesterol/phospholipid and phosphatidylcholine/sphingomyelin molar ratios are increased. Phospholipid fatty acid composition is also abnormal; the proportions of arachido...

We have developed a quantitative and relatively model-independent measure of lipid fluidity using EPR and have applied this method to compare the temperature dependence of lipid hydrocarbon chain fluidity, overall protein rotational mobility, and the calcium-dependent enzymatic activity of the Ca-ATPase in sarcoplasmic reticulum. We define membrane lipid fluidity to be T/eta, where eta is the v...

This paper introduces a novel method to quantify sociality in human and animal populations and explores the connection between social behaviour and the spread of infectious disease. Individuals living in groups tend to distribute their social effort heterogeneously, with some group members receiving more attention than others. By incorporating this heterogeneity into a mathematical model, we fi...

In this paper we discuss the fluidity of the hot and dense QCD matter created in ultrarelativistic heavy ion collisions in comparison with various other fluids, and in particular suggest its possible super-criticality. After examining the proper way to compare non-relativistic and relativistic fluids from both thermodynamic and hydrodynamic perspectives, we propose a new fluidity measure which ...

Insulin and Membrane Microviscosity of Erythrocytes as Risk Factors for Stroke To the Editor: I read with great interest the comments by Dr Kernan and colleagues1 dealing with the insulin sensitivity in nondiabetic patients with a recent transient ischemic attack or ischemic stroke. The results of their presented study demonstrated that pioglitazone may be effective for improving insulin sensit...

PURPOSE Deformability/rheologic behavior of erythrocytes are related to near-surface membrane fluidity. Specific agents can increase erythrocyte membrane fluidity in order to adjust hemodynamics in cardiovascular diseases. Grapefruit flavanone naringenin has been proposed for potential use in an alternative therapy of cardiovascular conditions. In respect to this, we assessed here effects of tw...