BACKGROUND Women are at great risk for mood and anxiety disorders during their childbearing years and may become pregnant while taking antidepressant drugs. In the treatment of depression and anxiety disorders, selective serotonin reuptake inhibitors (SSRIs) are the most frequently prescribed drugs, while it is largely unknown whether this medication affects the development of the central nervo...

Abstract There are concerns that microplastics act as a vector of pharmaceuticals in the aquatic environment. Most studies have focussed on pharmaceutical adsorption and not investigated desorption various matrices enter. Therefore we studied antidepressant drug fluoxetine from polyethylene terephthalate (PET) river water, sea simulated gastric intestinal fluids. We found most occurred rapidly,...

Some women in childbearing ages take selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine and fluvoxamine for treating psychiatric symptoms. However, these compounds may cause some side effects to their children. It has been identified that early life exposure to SSRIs increased the chance of developing mood disorders and the biological basis is still unclear. Here, we studied the...

The present study examines the consequences of prenatal fluoxetine exposure on brain serotonin [5-hydroxytryptamine (5-HT)] neurons in male offspring. Pregnant rats were administered either saline or fluoxetine (10 mg/kg s.c.) daily from gestational day 13 through gestational day 20. The biochemical status of brain 5-HT neurons was assessed in prepubescent and adult offspring by measuring 1) th...

Background: Fluoxetine (ProzacTM) is one of the most popular antidepressant that can be released to aquatic systems via sewage-treatment effluents. It is suspected to provoke substantial effects in the aquatic environment. Methods: In spawning tanks, specimens were exposed to concentrations of 0 and 0.54 µgl-1 fluoxetine from male introduction until the larvae had hatched. Prior to spawning, n...

background: fluoxetine (prozactm) is one of the most popular antidepressant that can be released to aquatic systems via sewage-treatment effluents. it is suspected to provoke substantial effects in the aquatic environment. methods: in spawning tanks, specimens were exposed to concentrations of 0 and 0.54 µgl-1 fluoxetine from male introduction until the larvae had hatched. prior to spawning, ne...

Early life events can significantly alter the development of the nociceptive circuit. In fact, clinical work has shown that maternal adversity, in the form of depression, and concomitant selective serotonin reuptake inhibitor (SSRI) treatment influence nociception in infants. The combined effects of maternal adversity and SSRI exposure on offspring nociception may be due to their effects on the...

OBJECTIVE Previous work suggested that first-trimester exposure to tricyclic antidepressants or fluoxetine does not affect adversely child IQ and language development. However, many women need antidepressants throughout pregnancy to avoid morbidity and suicide attempts. Little is known about the fetal safety of tricyclic antidepressants and fluoxetine when taken throughout pregnancy. The goal o...