PURPOSE The aim of the current study was to evaluate the efficacy and tolerability of hypo-fractionated whole breast radiation therapy in patients with early breast cancer. METHODS Searching electronically PubMed and the Cochrane Central Register we made a comprehensive literature review regarding the randomized controlled phase III trials for hypo-fractionated radiation therapy in early brea...

The neural system is less sensitive to radiation than other late-responding organs and tissues such as the kidney and lung. The generation of new neurons in the adult mammalian brain has been documented in several works. Many studies show that adult hippocampal neurogenesis relates to hippocampal function, in several ways. In this study, we assessed the effect of single and fractionated cobalt ...

The mammalian target of rapamycin (mTOR) modulates key signaling pathways that promote uncontrolled proliferation of glioblastoma multiforme (GBM). Because rapid tumor proliferation may contribute to the clinical radioresistance of GBM tumors, the combination of rapamycin, a selective mTOR inhibitor, and radiation was studied in vitro and in vivo in a GBM model. In monolayer cultures of U87 and...

Patients with residual or recurrent Cushing's disease receive external beam radiotherapy (RT) with the aim of achieving long-term tumour control and normalization of elevated hormone levels. Treatment is given either as conventional radiotherapy using conformal techniques or as stereotactic radiotherapy, which is either used as fractionated treatment (SCRT) or as single fraction radiosurgery (S...

Mapping out multidimensional potential energy surfaces has been a goal of physical chemistry for decades in the quest to both predict and control chemical reactivity. Recently a new spectroscopic approach called Femtosecond Stimulated Raman Spectroscopy or FSRS was introduced that can structurally interrogate multiple dimensions of a reactive potential energy surface. FSRS is an ultrafast laser...

BACKGROUND AND PURPOSE We compared the associations of self-reported atrial fibrillation (AF) and ECG-detected AF with incident stroke in the Risk of Stroke in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study. METHODS In this analysis, 27 109 participants aged 45 years or older without previous stroke were included. Stroke cases were identified and adjudicated durin...

We examine ultrafast dynamics in a coupled molecule-plasmon system. Using a new ultrafast Raman technique called surface enhanced-femtosecond stimulated Raman spectroscopy (SE-FSRS), we prove that plasmonic nanoparticles and adsorbed molecules are coupled by the appearance of Fano-like lineshapes, which arise from the interaction of narrowband vibrational coherences and the broadband plasmon re...

An initiative is undertaken by Bhabha Atomic Research Centre to extend affordable high quality neurosurgical practice in India. This automates the frameless Stereotaxy using a high precision 6 DOF Parallel Kinematic Mechanism (6D PKM) based Robot and a Surgical Coordinate Measuring Mechanism (SCMM). The system provides high accuracy as well as high patient comfort level as compared to conventio...