The mechanical microenvironment at a fracture site could potentially influence the outcomes of bone fracture healing. It is known that, should the fixation construct be too stiff, or the gap between the fracture ends be too large, bones are less likely to heal. Flexible fixation or so-called “biological fixation” has been shown to encourage the formation of fracture callus, and therefore result...

This paper reviews the available literature on effect of direct current on fracture healing; from a diagnostic view point. It also reviews various fracture treatments in practice, diagnostic tools, computational modeling and fracture healing prediction using Engineering techniques. We attempt to predict the complicated process fracture healing treated using DC electrical stimulation by computat...

Fracture healing is a specialized postnatal repair process that recapitulates many aspects of embryological skeletal development. While many of the molecular mechanisms that control cellular differentiation and growth during embryogenesis recur during fracture healing, these processes take place in a postnatal environment that is unique and distinct from those which exist during embryogenesis. ...

3 Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA The clinical role of prostaglandins in fracture healing has yet to be fully elucidated. Data from animal models have shown that some nonsteroidal anti-inflammatory medications (NSAIDs) inhibit fracture healing. However, a clear clinical association between prostaglandin inhibition and delayed fracture healing has not been ...

abstract : horizontal root fractures in permanent teeth are uncommon injuries among dental traumas. the principle of treating horizontal root fractures of permanent teeth is repositioning and fixation of fractured segment. diagnosis of tooth fractures based on radiographic findings and the fracture healing process are affected by factors before and after injury. the present case reports the tre...

Fracture healing requires two major pre-requisites; sufficient blood supply and mechanical stability [1-2]. Optimum mechanical conditions for fracture healing remain unknown, but micro-movements of the fracture fragments are significant to a developing healing callus [2-3]. This study uses Finite Element analysis to evaluate an idealized neck fracture callus, for single, and two lag screw intra...

Introduction Various compounds are being sought to increase fracture healing and enhance the healing rate. The closed femoral fracture in rats is a model commonly used to assess the efficacy of a compound for healing. This model is considered as a presumably stabilized fracture healing process. In a normal fracture healing process, there are 4 stages, i.e., inflammatory reaction and hematoma im...

INTRODUCTION Current methods of fracture care use various adjuncts to try and decrease time to fracture union, improve fracture union rates and enhance functional recovery. Intermittent pneumatic compression (IPC), one such modality, is used in the management of both fractures and soft-tissue injuries. METHODS AND RESULTS A search of PubMed, Medline, CINAHL, DH data and Embase databases was p...

BACKGROUND Bone metabolism is a complex system, and fracture healing is one of its most important functions. Many circumstances can influence this process. Chronic drug use in elderly populations can affect bone healing, and inadequate tissue perfusion, increased free radicals and adverse drug effects can negatively influence fracture healing. Nebivolol, an anti-hypertensive drug that selective...