OBJECTIVE To determine the proportion of patients with fragility fractures who can be expected to have low bone mineral density (BMD) at the time of fracture and to assist FPs in deciding whether to refer patients for BMD testing. DATA SOURCES MEDLINE, EMBASE, and CINAHL were searched from the earliest available dates through September 2009. STUDY SELECTION English-language articles reporti...

Our objective was to estimate the relationship between longitudinal change in BMD and fragility fractures. We studied 3635 women and 1417 men 50-85 yr of age in the Canadian Multicentre Osteoporosis Study who had at least two BMD measurements (lumbar spine, femoral neck, total hip, and trochanter) within the first 5 yr of the study and fragility fractures (any, main, forearm/wrist, ribs, hip) w...

BACKGROUND The presence of a fragility fracture is a major risk factor for osteoporosis, and should be an indicator for osteoporosis diagnosis and therapy. However, the extent to which patients who fracture are assessed and treated for osteoporosis is not clear. METHODS We performed a review of the literature to identify the practice patterns in the diagnosis and treatment of osteoporosis in ...

Osteoporosis is a metabolic disease characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to enhanced bone fragility and a consequent increase in fracture risk. Bone fragility depends on bone density, turnover and microarchitectural features, such as relative trabecular volume, spacing, number and connectivity. Previous fragility fractures increase the frac...

Purpose To evaluate the incidence of fragility fractures associated with high-dose glucocorticoid therapy in patients with systemic rheumatic disease. METHODS A retrospective study of patients who were treated with high-dose prednisolone (> 0.8 mg/kg) for systemic rheumatic disease at Kobe University Hospital from April 1988 to March 2012. The primary outcome was a major osteoporotic fracture...

Osteoporosis currently affects over twelve million Americans with another forty million affected by osteopenia or low bone mass [1]. Low bone mineral density has long been known to increase the risk of fragility fracture defined as “any fracture caused by injury that would be insufficient to fracture a normal bone”, typically occurring in the hip, vertebrae, wrist, and proximal humerus [2]. The...

Osteoporosis currently affects over twelve million Americans with another forty million affected by osteopenia or low bone mass [1]. Low bone mineral density has long been known to increase the risk of fragility fracture defined as “any fracture caused by injury that would be insufficient to fracture a normal bone”, typically occurring in the hip, vertebrae, wrist, and proximal humerus [2]. The...

BACKGROUND HIV infection has been associated with an increased risk of fragility fracture. We explored whether or not this increased risk persisted in HIV infected and uninfected men when controlling for traditional fragility fracture risk factors. METHODOLOGY/PRINCIPAL FINDINGS Cox regression models were used to assess the association of HIV infection with the risk for incident hip, vertebra...

INTRODUCTION Fragility fractures are an important public health issue. The aim of this study was to analyze the association of the main osteoporotic risk factors related to fragility fracture in a cohort of women with an indication of bone densitometry (BD). METHODS A retrospective cohort was followed-up until a fragile fracture occurred, in a population of women aged 40 to 90 years with a fi...