In Homework 1, we did a problem where we calculated the parameters of the Framingham risk score for predicting cardiovascular disease (CVD). In this problem, we will revisit the parameters of the Framingham risk score in a more realistic setting using the more sophisticated optimization tool of linear least squares. In the problem in Homework 1, we determined four parameters of Framingham risk ...

BACKGROUND Several studies have shown associations between hyperglycemia and risk of cardiovascular disease (CVD) and mortality, yet glucose-lowering treatment does little to mitigate this risk. We examined whether associations between hyperglycemia and CVD risk were explained by underlying insulin resistance. METHODS In 60 middle-aged individuals without diabetes we studied the associations ...

INTRODUCTION To compare the performance of the Framingham and SCORE functions to estimate fatal cardiovascular events. In addition, we explored the ability of both functions to detect the risk contributed by factors not included in their equations: sedentariness, obesity, abdominal circumference, abdomen/height razón, abdomen/pelvis ratio, and excessive alcohol consumption. METHODS We perform...

Introduction: Cardiovascular diseases (CVD) are the world’s most common cause of death. The Framingham risk score (FRS) is commonly used method for CVD assessment. Low-risk individuals have 10% or less coronary heart (CHD) at 10 years, 10-20% intermediate risk and 20% more high risk. Aim Work: To estimate of developing cardiovascular over next ten years among administrativestaff Zagazig Univers...

BACKGROUND Screening tools to identify persons with high cardiovascular risk exist, but less is known about their validity in different population groups. The aim of this article is to compare the sensitivity and specificity of three different cardiovascular disease risk scores and their ability to detect high-risk individuals in daily practice. METHODS The sensitivity and specificity of risk...

BACKGROUND Neither clinical prediction models nor noninvasive imaging tests that detect coronary artery calcification identify all patients who experience acute coronary events. Variations in culprit plaque morphology may account for these inaccuracies. METHODS AND RESULTS We compared the 10-year Framingham risk index, histologic coronary calcification, and culprit plaque morphology in 79 con...

Background Current evidence on associations of type-specific sedentary behavior with cardiovascular disease (CVD) is limited to mainly screen-time sedentary behavior (SB). We aimed to study the associations of type-specific and total time spent sitting with the Framingham 10-year cardiovascular disease risk score (Framingham score) in Finnish adults. Methods Data comprise the National FINRISK...

INTRODUCTION AND OBJECTIVES To determine which cardiovascular risk function is best for classifying high-risk individuals on statins. METHODS Descriptive cross-sectional study of 804 randomly selected patients aged 35-74 years. Variables studied included statin treatment, high cardiovascular risk according to Framingham-REGICOR (10-year risk >or=10%), Framingham-Wilson (10-year risk >or=20%) ...

OBJECTIVE Consensus guidelines recommend cardiovascular risk assessment as the initial step of primary prevention. The aim of this study was to evaluate the incremental predictive value for coronary events conferred by carotid ultrasonography in addition to risk assessment by Framingham score and screening for silent myocardial ischemia in a cohort of type 2 diabetic patients. RESEARCH DESIGN...