Research on Ebola virus (EBOV) has focused on preventing and controlling the infection using vaccines and antiviral therapies. Given the long-term challenge of the current epidemic and the likelihood of future outbreaks of viral hemorrhagic fevers caused by the filoviruses, including EBOV and Marburg virus, efforts should also focus on developing therapies to reduce the deadly complications of ...

Hyperpigmentation over face in a neonate is rare and the differentials for the same are also rare. Congenital chickengunya, fungal and viral infections, drug rash are few differentials. Chikungunya virus (CHIKV) infection manifesting in neonates is very rare. The prevalence of the entity was described only recently. We describe a neonate with hyperpigmentation on day 3 of life with stormy cours...

OBJECTIVE Thrombocytopenia is commonly observed in very low birth weight (VLBW) neonates with sepsis. Specific platelet responses to different infectious agents have not been extensively characterized. The objectives of this study were to examine platelet counts and platelet indices in preterm neonates with culture-proven sepsis to determine if there are organism-specific platelet responses. ...

Fluconazole has been used as prophylaxis against systemic fungal infections in preterm neonates. We conducted a study to determine whether cessation of a policy of prophylactic fluconazole results in a resurgence of fungal infections in a unit. Neonates born in the 3 epoches: A 36-month pre-Fluconazole prophylaxis epoch (Group 1), a 21-month Fluconazole prophylaxis epoch (Group 2) and a 39-mont...

introduction fungal prosthetic valve endocarditis (pve) is rare but serious complication of valve replacement surgery. candida species, particularly candida albicans is the most common isolated pathogen in fungal pve (1–6%of cases). case presentation we describe a 35-year-old woman who underwent mechanical mitral valve replacement about 3 years ago. she was admitted with neurological symptoms a...

INTRODUCTION In our clinical practice, we observed high interleukin-6 (IL-6) levels in gram-negative sepsis. OBJECTIVE To investigate the relationship between IL-6 and C-reactive protein (CRP) levels and early determination of neonatal sepsis of gram-negative or gram-positive aetiology. POPULATION AND METHODS White blood cell count, IL-6 and CRP levels were compared among different groups. ...

BACKGROUND Invasive fungal sepsis has become the third most common cause of late-onset infections in many neonatal intensive care units (NICU). The prevalence rate ranges from 2.6% to 16.7% among very-low-birth-weight infants and from 5.5% to 20% among extremely low-birth-weight infants. Despite the development of several new antifungal agents in the past few years, the management of serious fu...

Identifying neonates with sepsis is complicated by variability in clinical presentation. The incidence of early onset sepsis (EOS) resulting from invasive group B streptococcal (GBS) infections has been notably reduced by the widespread delivery of intrapartum antibiotic prophylaxis. Rates of EOS attributable to non-GBS etiologies have remained constant, and ampicillin-resistant Escherichia col...

Endogenous fungal endophthalmitis (EFE) is a rare but serious complication of fungal sepsis and the incidence has increased in the past half century because of the advent of antibiotics and indwelling catheters [1]. The most common cause of culture-proven EFE is Candida species [2]. Although a particular therapeutic regimen has not been prospectively established, treatment options can include i...

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection.1 It frequently leading death from septic shock and multi failure worldwide. can be any infection, either fungal, viral, parasitic, or bacterial, not all of these pathogens cultured. In around half patients with sepsis, no pathogen identified.2 For every hour delayed treatment the risk mortality sep...