The hitherto unknown (±)-4-methoxydecanoic acid was synthesized in six steps and in 25% overall yield starting from commercially available 4-penten-1-ol. The title compound demonstrated seventeen fold higher antifungal activity (MIC = 1.5 mM) against Candida albicans ATCC 60193 and Cryptococcus. neoformans ATCC 66031 when compared to unsubstituted n-decanoic acid. Our results demonstrate that M...

Essential oils obtained from plants have recently gained a great scientific interest as a potent source of antimicrobials of natural origin. The present study highlights the antifungal activity of essential oils against Aspergillus flavus and Aspergillus niger. During screening of essential oils of six selected Angiospermic plants at 2000 ppm (mg/l) against the test fungus, Mentha arvensis and ...

Removal of 1 or more sugar residues from the alpha-tomatine molecule markedly decreased its fungitoxicity. While partial hydrolysis of alpha-tomatine did not greatly affect its surfactant properties, it did destroy the ability of this alkaloid to form a complex with cholesterol. Only unprotonated alpha-tomatine was capable of binding cholesterol; the protonated form did not. Since alpha-tomatin...

BACKGROUND AND AIMS Control of diseases in the key tropical staple, cassava, is dependent on resistant genotypes, but the innate mechanisms are unknown. The aim was to study phenylpropanoids and associated enzymes as possible defence components. METHODS Phenylalanine ammonia-lyase (PAL), phenylpropanoids and peroxidases (POD) were investigated in elicited cassava suspension cells and leaves. ...

In vitro fungitoxic activity of Cannabis sativa leaf extracts against Phytopthora capsici isolated from (Solanum Tuberosum potato and Capsicum annuum) was studied in acetone, ethanol, methanol, water various solvents. The food poisoning technique used to measure fungitoxicity, which comprised utilising different at 200mg/ml documenting their as radial growth percentage inhibition. only that tot...