As the incidence and already high mortality rates of malignant melanoma have been steadily increasing in recent decades, the early detection and excision of malignant melanoma have imposed as the most important task. Staging of malignant melanoma is determined according to the level of invasion (Clark level) and vertical thickness (Breslow scale). Besides operative therapy, which is the only ef...

Triphenylethylene structures similar to tamoxifen (Nolvadex) were first used in the 1940s, but in comparison to synthetic and natural estrogens used at that time, they were not particularly potent antitumor agents. [1,2] Tamoxifen was introduced into the clinic in 1969. Because of its much improved toxicity profile over the estrogens and androgens in use at that time, it rapidly gained acceptan...

It has long been recognized that delayed emesis can be difficult to control. As many as 90% of patients receiving high-dose cisplatin regimens ( 120 mg/m2) are reported to experience delayed nausea or vomiting despite antiemetic prophylaxis with high-dose metoclopramide and dexamethasone on the day of cisplatin treatment. The incidence of symptoms is greatest between 48 and 72 hours after cispl...

Triphenylethylene structures similar to tamoxifen (Nolvadex) were first used in the 1940s, but in comparison to synthetic and natural estrogens used at that time, they were not particularly potent antitumor agents. [1,2] Tamoxifen was introduced into the clinic in 1969. Because of its much improved toxicity profile over the estrogens and androgens in use at that time, it rapidly gained acceptan...

Ataxia-telangiectasia (A-T) is an autosomal recessive multi-system disorder caused by mutation in the ataxia-telangiectasia mutated gene (ATM). ATM is a large serine/threonine protein kinase, a member of the phosphoinositide 3-kinase-related protein kinase (PIKK) family whose best-studied function is as master controller of signal transduction for the DNA damage response (DDR) in the event of d...

The Relationship between Organizational Socialization and Organizational Identity among Physical Education Teachers in Cities of Tehran Province   Sh. Nazari, Ph.D.[1]   This study set out to examine the relationship between organizational socialization and organizational identity among physical education teachers in cities of Tehran province. This applied research had a correlational desig...