نتایج جستجو برای: gabapentin
تعداد نتایج: 2699 فیلتر نتایج به سال:
The aim of this open-label, randomized, and 3-period crossover study was to evaluate the influences of concomitant antacid administration on the plasma disposition, intestinal absorption, and urinary excretion of gabapentin in humans. Gabapentin (200 mg) was orally administered alone, with 1 g magnesium oxide (MgO), or with 20 mg omeprazole to 13 healthy adult subjects. Oral bioavailability (BA...
gabapentin is an anticonvulsant widely used in the treatment of epilepsy.an accurate and validated spectrophotometric method was developed as an alternative method to determine gabapentin in pharmaceutical products. this is a simple, accurate, precise, selective and visible spectrophotometric method. the method is based on the measurement of drug absorbance as a result of yellow solution format...
Gabapentin is being used in horses although its pharmacokinetic (PK) profile, pharmacodynamic (PD) effects and safety in the equine are not fully investigated. Therefore, we characterized PKs and cardiovascular and behavioral effects of gabapentin in horses. Gabapentin (20 mg/kg) was administered i.v. or p.o. to six horses using a randomized crossover design. Plasma gabapentin concentrations we...
background complications and postoperative pain are major care problems that can affect the quality of health care plan. objectives according to the use of multimodal therapy the current study aimed to compare the efficacy of gabapentin and celecoxib in pain management and complications after laminectomy at ilam university of medical sciences, ilam, iran, in 2015. patients and methods in this r...
BACKGROUND Gabapentin is an antiepileptic drug. It is structurally similar to yaminobutyric acid (GABA), which crosses the blood-brain barrier. Gabapentin is absorbed into the blood by the L-amino acid transport system. The oral bioavailability of gabapentin displays dose-dependence. Plasma concentrations ofgabapentin are not directly proportional to dose. Therefore, pharmacokinetic of gabapent...
FMOC-Cl is a derivatizing agent widely used both in N-protection reactions of a-amino acids as well quantification and detection amino related molecules using HPLC-PDA or fluorescence analysis. In this work we studied the reaction with gabapentin. However, it was observed that degradation gabapentin-N-FMOC to FMOC-OH occur simultaneously presence basic medium which specific for gabapentin deriv...
Gabapentin is used as an effective drug for relieving pain, but the main mechanism is still unclear. Recently, voltage-gated Ca channel subunits are suggested for the main target for the analgesic action of gabapentin. We wonder whether gabapentin directly modulates other specific ion channels peripherally expressed in the sensory neurons. To test this, we used a heterologous expression system ...
The FDA approved gabapentin enacarbil in 2011 as the first non-dopaminergic agent for the treatment of restless legs syndrome (RLS) symptoms. Although gabapentin enacarbil is a pro-drug of gabapentin, its pharmacokinetics differ. Absorption of gabapentin enacarbil is more predictable, and inter-patient variability in bioavailability is lower than that of gabapentin. Studies have demonstrated su...
Restless legs syndrome (RLS) is a sleep-related movement disorder commonly involving an unpleasant urge to move the limbs, typically the legs. Dopaminergic agents represent the first-line therapy for RLS; however, long-term use of such drugs results in worsening symptoms due to "augmentation" or other adverse events. Gabapentin, an analog of the inhibitory neurotransmitter gamma-aminobutyric ac...
Angioedema is a known potential side effect of gabapentin; however, not many reports presentation exist in literature. This report 31-year-old woman who presented with signs sciatica and was started on gabapentin. When the gabapentin dosage increased, she developed angioedema right her face, particularly pronounced periorbital region. Because an acute allergic reaction suspected at first, patie...
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