The integrin avb3 is a key player in angiogenesis and metastasis. Our aim was to study the uptake patterns of the avb3-selective PET tracer 18F-galacto-RGD in invasive ductal breast cancer. Methods: Sixteen patients with primary (n 5 12) or metastasized breast cancer (n 5 4) were examined with 18F-galacto-RGD PET. Standardized uptake values (SUVs) were derived by region-ofinterest analysis, and...

in this study, the milk-derived galactooligosaccharides (gos) were produced by lactobacillus delbrueckii subsp. bulgaricus and refined by an ultrafiltration-nanofiltration continuous membrane. by further investigation, we found that the gos product purified by gel permeation chromatography mainly contained low molecular weight disaccharide and trisaccharide, that is, 4-β-galactobiose and tri-ga...

Compelling evidence links enteric microbes to brain function and behavior. Galacto-oligosaccharide prebiotics have been shown modulate the composition of gut flora induce metabolic, neurochemical, behavioral changes in adult rodents. Despite being most susceptible environmental factors, such as nutrients toxins, during earliest stages development, it is unknown whether maternal prebiotic supple...

The complete lacto-N-biose I/galacto-N-biose metabolic pathway in 1 Bifidobacterium longum: identification of N-acetylhexosamine 1-kinase* 2 3 Mamoru Nishimoto and Motomitsu Kitaoka 4 National Food Research Institute, 2-1-12 Kannondai, Tsukuba, Ibaraki 305-8642, Japan 5 6 Running title: Lacto-N-biose I/galacto-N-biose pathway in bifidobacterium 7 8 Corresponding author. Mailing address: Nationa...

We construct a Galacto-Local Group rotation curve, combining the Galactic rotation curve with a diagram, where galacto-centric radial velocities of outer globular clusters and member galaxies of the Local Group are plotted against their galacto-centric distances. The high-velocity ends of this pseudo rotation curve within a radius R ∼ 150 kpc are well traced by a rotation curve calculated for t...

Different conformations of methyl 3,6-anhydroglycosides with the beta-D-galacto, alpha-D-galacto, and beta-D-gluco configurations were studied by molecular mechanics (using the program mm3) and by quantum mechanical (QM) methods at the HF/- and B3LYP/6-31+G** levels, with and without solvent emulation. Using molecular mechanics, the energies were plotted against the phi, theta puckering coordin...

Constipation is a common problem and its prevalence increases with age. Severe constipation requires treatment with laxatives, but nutritional therapy, especially increased dietary fibre intake, is recommended primarily for the prevention and treatment of mild constipation. One alternative may be the use of oligosaccharides, which act as soluble fibre and have a bifidogenic effect. Galacto-olig...

UNLABELLED Human milk oligosaccharides are not digested during intestinal passage and can be detected in stools. In this study it was investigated whether a prebiotic mixture of low-molecular-weight galacto-oligosaccharides (GOS) and high-molecular-weight fructo-oligosaccharides (FOS) can be detected in stool samples of formula-fed infants. The test formula was supplemented with 0.8 g/dl oligos...