Strain PA14, a human clinical isolate of Pseudomonas aeruginosa, is pathogenic in mice and insects (Galleria mellonella). Analysis of 32 different PA14 mutants in these two hosts showed a novel positive correlation in the virulence patterns. Thus, G. mellonella is a good model system for identifying mammalian virulence factors of P. aeruginosa.

EditoriAL Pathogens and their respective hosts interact closely leading to the host–pathogen framework response that could result in different outcomes that range from pathogen elimination to death of the host. To improve our ability to propose new measures that promote pathogen elimination and prevent host death, we need to have a comprehensive understanding of this interaction. Generally , mo...

Indole-3-acetonitrile obtained from cabbage has been found to inhibit growth of Pyrausta nubilalis (Hbn.), Galleria mellonella (L.), and Penicillium chrysogenum.

The hemolymph juvenile hormone binding protein (JHBP) from Galleria mellonella contains two disulphide bridges/molecule and no free Cys residues. An alignment of primary structures of other Lepidopteran JHBPs indicates that Cys residues, equivalent to Cys10,17,151,195 in G. mellonella JHBP, maybe involved in -S-S- bridge formation.

The present study was conducted to determine the impact of nanoparticles (TiO2 and ZnO) at concentrations (100,500,1000,5000) ppm Bacillus thuringiensis spores concentration (106 and109 cells/ml D.W on some biological aspects greater ,108 107 wax moth(Galleria mellonella) . results showed that these materials have a significant effect development stages, larva pupa Galleria mellonella .The had ...

We report the use of antimicrobial hemolymph proteins from the model host Galleria mellonella as an inhibitor for various Listeria strains, providing a novel source for antilisterial therapeutics. We also have shown that specific virulence-associated genes known to mediate antimicrobial resistance of Listeria in mammalian models indicated a similar function in Galleria.

An essential factor to the virulence of the genus Candida is the ability to produce enzymes and this may be crucial in the establishment of fungal infections. Aim: This study investigated in vitro enzymatic activities of Candida species and their virulence in an in vivo Galleria mellonella experimental model. Methods: Twenty-four clinical strains of Candida spp. isolated from the human oral cav...

entomopathogenic fungi produce secondary metabolites which may bioactively help fungus in its virulence toward insect hosts. beauveria bassiana produces several toxic low molecular compounds in vitro as well as in vivo, the most important of them is beauvericin. the beh isolate of the fungus was selected for beauvericin assay. beauvericin was obtained from surface and submerged cultures of the ...

The inducible metalloproteinase inhibitor (IMPI) discovered in Galleria mellonella is currently the only specific inhibitor of metalloproteinases found in animals. Its role is to inhibit the activity of metalloproteinases secreted by pathogenic organisms as virulence factors to degrade immune-relevant polypeptides of the infected host. This is a good example of an evolutionary arms race between...