Bone has an enormous capacity for growth, regeneration, and remodeling. This capacity is largely due to induction of osteoblasts that are recruited to the site of bone formation. The recruitment of osteoblasts has not been fully elucidated, though the immediate environment of the cells is likely to play a role via cell- matrix interactions. We show here that heparin-binding growth-associated mo...

Geodesic acoustic mode (GAM) of electrostatic and density fluctuations are simultaneously measured by Heavy Ion Beam Probe and Correlation Reflectometry. The local values of electric potential and density fluctuations demonstrate the significant coherency and constant phase shift at GAM frequency range. The existence of the long-distance (one quarter of the torus) correlations of electric poten...

The heparin binding molecules MK and HB-GAM are involved in the regulation of growth and differentiation of many tissues and organs. Here we analyzed the expression of MK and HB-GAM in the developing mouse incisors, which are continuously growing organs with a stem cell compartment. Overlapping but distinct expression patterns for MK and HB-GAM were observed during all stages of incisor develop...

A field experiment was carried out in the Light village of Netrokona Sadar during the period from December 2010 to March 2011 to study the performance of some wheat varieties in terms of nutrient contents and their uptake. The experiment comprised of five varieties of wheat viz. BARI Gam 25, Shatabdi, BARI Gam 26, Prodip and Bijoy. The experiment was laid out in a randomized complete block desi...

The coexistence of intensive low frequency zonal flows (LFZFs) and geodesic acoustic modes (GAMs) has been observed by identifying the spatial characteristics, i.e. the symmetries in poloidal and toroidal directions, and the finite radial wave number, using three-dimensional Langmuir probe arrays in the edge plasmas of HL-2A tokamak. The analysis of three wave coupling with ambient turbulence s...

BACKGROUND Generalized Additive Model (GAM) provides a flexible and effective technique for modelling nonlinear time-series in studies of the health effects of environmental factors. However, GAM assumes that errors are mutually independent, while time series can be correlated in adjacent time points. Here, a GAM with Autoregressive terms (GAMAR) is introduced to fill this gap. METHODS Parame...

The ability of anti-chicken smooth-muscle actomyosin y-globulins (anti-GAM) to inhibit the aggregation of dissociated cells from the skeletal muscle and liver of chick embryos was abolished by pretreatment of the anti-GAM with either myosin or heavy meromyosin (HMM). When the same cells were treated with HMM at a concentration of 1 mg per 2x10' cells/ml Eagle's MEM they aggregated as readily as...

Effective methods for metrics definition are of particular importance, as measurement mechanisms are indispensable in virtually any engineering discipline. The paper describes how the well known Goal-Question-Metric (GQM) method of systematic metrics derivation from measurement goals can be extended by applying argument structures. The proposed approach is called Goal-Argument-Metric (GAM). The...

The current dogma in neural regeneration research implies that chondroitin sulfate proteoglycans (CSPGs) inhibit plasticity and regeneration in the adult central nervous system (CNS). We argue that the role of the CSPGs can be reversed from inhibition to activation by developmentally expressed CSPG-binding factors. Heparin-binding growth-associated molecule (HB-GAM; also designated as pleiotrop...

MicroRNAs (miRNAs) are small regulatory RNAs targeting multiple effectors of cell homeostasis and development, whose malfunctions are associated with major pathologies such as cancer. Herein we show that GAM/ZFp/ZNF512B works within an intricate gene regulatory network involving cell-cycle regulators, TGFβ effectors and oncogenic miRNAs of the miR-17-92 cluster. Thus, GAM impairs the transcript...