Vortioxetine is an antidepressant with multiple pharmacologic modes of action at targets where serotonin neurons connect with other neurons. These actions modify the release of both glutamate and GABA (gamma amino butyric acid) within various brain circuits.

Clinical disorders known to affect inherited gamma-amino butyric acid (GABA) metabolism are autosomal recessively inherited succinic semialdehyde dehydrogenase and GABA-transaminase deficiency. The clinical presentation of succinic semialdehyde dehydrogenase deficiency includes intellectual disability, ataxia, obsessive-compulsive disorder and epilepsy with a nonprogressive course in typical ca...

background: searching for factors that reduce the adverse effect of heat stress (hs) on broiler performance has particular importance. objectives: the present study was designed to investigate the influence of dietary melatonin, gamma-amino butyric acid (gaba) and dark period on growth performance, carcass characteristics and blood parameters of broiler under heat stress condition. methods: a t...

Submit Manuscript | http://medcraveonline.com Abbreviations: ANOVA: Analysis of Variance; CBT: Cognitive Behavior Therapy; GABA: Gamma Amino Butyric Acid; GAD: Generalized Anxiety Disorder; OCD: Obsessive Compulsive Disorder; SAD: Social Anxiety Disorder; PTSD: Post-Traumatic Stress Disorder; SNRI: Serotonin Norepinephrine Reuptake Inhibitors; SPSS: Statistical Package for Social Sciences; SSRI...

UNLABELLED Inhaled anesthetics produce immobility (a cardinal aspect of general anesthesia) by an action on the spinal cord, possibly by potentiating the responses of gamma-amino-n-butyric acid (GABA(A)) and glycine receptors to GABA and glycine. In this study, we antagonized GABA(A) and glycine responses by intrathecal administration of picrotoxin (a noncompetitive GABA(A) antagonist), strychn...

HNE 4-Hydroxy-2-nonenal 5-HT 5-Hydroxytryptamine ATPase Adenosine triphosphatase ALA Alpha-lipoic acid DNA Deoxyribonucleic acid GABA Gamma-amino butyric acid GPX Glutathione peroxidase GAP43 Growth-associated protein 43 NAD+ Nicotinamide adenine dinucleotide oxidized NADP+ Nicotinamide adenine dinucleotide phosphate oxidized NADHP Nicotinamide adenine dinucleotide phosphate reduced NADH Nicoti...

background: neurotransmitter release is an essential link in cell communication of the nervous system. many investigations have focused on gamma amino butyric acid (gaba)-ergic neurotransmission, because it has been implicated in the pathophysiology of several central nervous system disorders. to bypass complications related to homo- and heterosynaptic modulation and to avoid indirect interpret...

Abbreviations: CRH: Corticotropin Releasing Hormone; CRH1: Corticotropin Releasing Hormone Receptor; CSF: Cerebro Spinal Fluid; D2: Dopaminergic Subreceptor; GABA: Gamma Amino Butyric Acid; GABAA: Gamma-Aminobutyric Acid Subtype A Receptors; GABAB: Gamma-Aminobutyric Acid Subtype B Receptors; Gal2: Galanin 2; 5-HT: Serotonergic Receptor; 5-HT1A: 5-Hydroxytryptamine 1A Receptors; 5-HT7: 5-hydrox...

OBJECTIVE The goal of this study was to analyze magnetic resonance imaging findings of gamma-amino butyric acid and gamma deuteroxy sodium butyrate and to evaluate possible "in vitro" and "in vivo" areas of use. MATERIALS AND METHODS Materials used included gamma-amino butyric acid and gamma deuteroxy sodium butyrate which is formed by the replacement of the deuteroxy group. An amino group in...