The ROC (Receiver Operating Characteristics) curves are frequently used to measure the effectiveness of diagnostic biomarkers. A global measure of the ROC curve is the Youden index, the maximum difference between sensitivity and 1-specificity. The cut-point is the value for which the maximum is attained. In this paper we obtain the asymptotic distribution of the optimal cut-point under the assu...

Charge movement was measured in frog cut twitch fibers with the double Vaseline gap technique. Five manipulations listed below were applied to investigate their effects on the hump component (I gamma) in the ON segments of TEST minus CONTROL current traces. When external Cl-1 was replaced by MeSO3- to eliminate Cl current, I gamma peaked earlier due to a few millivolts shift of the voltage depe...

The theoretical study of serum prolactin response to TRH during antithyroid treatment in hyperthyroid patients was determined. Formulae of fuzzy gamma distributions, fuzzy reliability functions and its  -cut sets are presented. Using a Fuzzy reliability analysis based on gamma distribution, we showed that changes from normal serum levels of T3 and T4 are associated with changes in prolactin re...

Several biological markers have been proposed to improve the efficacy of diagnosing tuberculous pleurisy. The study was undertaken to evaluate the accuracy of pleural fluid adenosine deaminase (ADA) activity and interferon-gamma (IFN-gamma) concentration in differentiating tuberculous pleural effusion (TPE) and nontuberculous pleural effusion (non-TPE). Ninety four patients (50 M and 44 F, mean...

We conducted a randomised prospective comparison of the Compression Hip Screw(CHS) and gamma nail for internal fixation of 60 intertrochanteric femoral fractures in elderly patients. The gamma nail group showed shorter convalescence and earlier full weight-bearing. There were however no significant differences in the operative time, blood loss, stay in hospital' and patien's mobility at the fin...

Amplitudes of the form $\gamma^*(q^2)\to \gamma P_1P_2$ appear as sub-processes in computation muon $g-2$. We test a proposed theoretical modelling against very precise experimental measurements by KLOE collaboration at $q^2=m^2_\phi$. Starting from an exact parameter-free dispersive representation for $S$-wave satisfying QCD asymptotic constraints and Low's soft photon theorem we derive, effec...

My thesis deals with a fundamental question of high energy gamma-ray astronomy. Namely, I studied the cut-off shape of the Crab pulsar spectrum to distinguish between the leading scenarios for the pulsar models. Pulsars are celestial objects, which emit periodic pulsed electromagnetic radiation (pulsation) from radio to high energy gamma-rays. Two major scenarios evolved in past 40 years to exp...

BACKGROUND Failure of passive transfer of maternal immunity via colostrum can occur in the bovine, and a number of blood tests have been developed to test calves for this failure. It is not clear which test is most suitable for this purpose. The objective was to examine the most commonly used tests for failure of passive transfer and to decide which is most suitable for routine laboratory use. ...

The gamma interferon (gamma-IFN) concentration and the adenosine deaminase (ADA) activity were evaluated in 30 patients with tuberculous peritonitis, 21 patients with ascites due to a malignant disorder, and 41 patients with cirrhosis. The gamma-IFN concentrations were significantly higher (p < 0.0001) in tuberculous peritonitis patients (mean: 6.70 U/ml) than in the malignant (mean: 3.10 U/ml)...