NEW DRUGS Cervical Cancer Vaccine The Food and Drug Administration (FDA) has approved Gardasil (Merck), the first vaccine developed to prevent cervical cancer, precancerous genital lesions, and genital warts caused by human papilloma virus (HPV) types 6, 11, 16, and 18 for females nine to 26 years of age. This agent was evaluated and approved in six months under the FDA’s priority review proces...

Vaccination is generally considered safe in patients with multiple sclerosis (MS). We report five patients who presented with multifocal or atypical demyelinating syndromes within 21 days of immunization with the quadrivalent human papilloma virus (HPV) vaccine, Gardasil. Although the target population for vaccination, young females, has an inherently high risk for MS, the temporal association ...

BACKGROUND The national human papillomavirus (HPV) vaccination roll-out in South Africa provides two doses of Cervarix to all female Grade 4 learners in state schools. This study estimated the costs of vaccinating all learners in KwaZulu-Natal Province (females or males and females) using either the two- or three-dose strategies for both the bivalent and quadrivalent vaccines. OBJECTIVE To de...

Late September saw the Michigan Senate approve two bills that will require girls in Michigan entering the sixth grade to be vaccinated against the two strains of the sexually transmitted virus human papillomavirus (HPV) that cause 70% of all cervical cancers. The two bills, if approved by the State Assembly, will mean that starting in the 2007–2008 school year, parents in Michigan will be the f...

Ninety-one HIV-infected individuals (61 men and 30 women) were randomized to vaccination either with quadrivalent (Gardasil™) or bivalent (Cervarix™) HPV vaccine. Neutralizing and specific HPV-binding serum antibodies were measured at baseline and 12 months after the first vaccine dose. Presence of neutralizing and binding antibodies had good agreement (average Kappa for HPV types 6, 11, 16, 18...

BACKGROUND The current generation of Human Papillomavirus (HPV) vaccines, Cervarix® and Gardasil®, exhibit a high degree of efficacy in clinical trials against the two high-risk (HR) genotypes represented in the vaccines (HPV16 and HPV18). High levels of neutralizing antibodies are elicited against the vaccine types, consistent with preclinical data showing that neutralizing antibodies can medi...