Protein glycation involves formation of early (Amadori) and late advanced glycation endproducts (AGEs) together with free radicals via autoxidation of glucose and Amadori products. Glycation and increased free radical activity underlie the pathogenesis of diabetic complications. This study investigated whether aged garlic has more potent antiglycation and antioxidant properties compared to fres...

Recent studies have shown that deoxygenated human red blood cells (RBCs) converted garlic-derived polysulfides into hydrogen sulfide, which in turn produced vasorelaxation in aortic ring preparations. The vasoactivity was proposed to occur via glucose- and thiol-dependent acellular reactions. In the present study, we investigated the interaction of garlic extracts with human deoxygenated RBCs a...

background: garlic (allium sativum) is known for its anti-bacterial properties, but information on its effects against bacteria species that are important in fish diseases is scarce. objectives: the aim of this research was to use garlic as a natural product to improve the aquatic animal health status so as to compensate the demand for environment-friendly products for sustainable aquaculture. ...

To study antimicrobial activity of shallot in comparison with that of garlic and onion against 23 strains of fungi and bacteria, water extracts of garlic, shallot and onion bulbs were prepared. Each extract was studied in different forms for their antimicrobial activity viz., fresh extract, dry extract and autoclaved extract. Minimal inhibitory concentration and minimal lethal concentrations of...

The protective effect of garlic extract in chromium induced genotoxicity was evaluated using analysis of chromosomal aberrations in somatic cells of mice in in vivo animal model. Three doses of garlic extracts were selected for modulation and administered to animals after priming with chromium all the animals were killed after 24 hrs of treatment and the mitotic preparations were made. A signif...

Introduction. Garlic (Allium sativum) is believed to have been originated from Central Asia over 6,000 years ago, but has spread to almost everywhere long time ago. Garlic is the edible bulb of the lily family, Liliaceae. It is a relative of the onion and leek, and other related species containing the aromatic sulfur-based compounds, which contribute to the characteristic odor and taste, as wel...

objective(s)  garlic (allium sativum) is known as a potent spice and a medicine with broad therapeutic properties ranging from antibacterial to anticancer, and anticoagulant. one of the major purified garlic protein components is the 47 kda protein. in this study, the effect of 47 kda protein extracted from aged garlic (age) was evaluated on mouse dendritic cell (dc) maturation in vitro. materi...

Cyclophosphamide (CP) is a commonly used chemotherapeutic and immunosuppressive agent which is used in the treatment of wide range of cancers and autoimmune diseases. Besides that it is a well known carcinogen. In this study by using chromosomal aberrations (CA) and sister chromatid exchanges (SCE) assays method, the modulatory effects exerted by the extract of garlic against the CP induced gen...

Neoparamoeba pemaquidensis believed to be the most prevalent parasite of Atlantic salmon industry in Australia. In the present study, the in vitro effects of crude extract of garlic and metronidazole were investigated using a primary culture toxicity assay. Garlic extract appeared to be completely effective at killing a cultured strain (NP251002) of Neoparamoeba pemaquidensis in vitro at a dilu...

BACKGROUND The study was aimed to show the effect of molecular mechanism of Aqueous Garlic Extract (AGE) on expression of IFNγ and iNOS genes in Leishmania major. METHODS Leishmania major promastigotes (MRHO/IR/75/ER) were added to the in-vitro cultured J774 cell line, the cells were incubated for 72 hours. Various concentrations of garlic extract (9.25, 18.5, 37, 74, 148 mg/ml) were added to...