Objective(s) The liver has major role in the organism homeostasis, interactions with other systems, synthesis and metabolism of bile production, drug detoxification and hormone inactivation. Cholestasis can be defined as an impairment of the bile flow which can lead to hepatocytes necrosis and finally cirrhosis. Some studies reported a gastric acid secretion reduction in cirrhotic subjects, wh...

it is well established that the esophageal distention (ed) leads to gastric relaxation, partly by vago-vagal reflex, but till now, the effect of ed on gastric acid secretion has not been investigated. the aim of this study was to investigate the effect of ed on basal and stimulated gastric acid secretion. methods: adult male wistar rats (200-240 g) were deprived of food but not the water 24 h b...

background: opioid peptides and their receptors are present in the majority of body tissues including gastrointestinal tract.  heroin is one of the opioid derivatives that abuse increasingly today.  so far, there is no study on the effect of acute heroin administration on gastric acid and pepsin secretion.   objective:  to define the effect of the acute heroin consumption on basal and vagal-sti...

objective(s) the liver has major role in the organism homeostasis, interactions with other systems, synthesis and metabolism of bile production, drug detoxification and hormone inactivation. cholestasis can be defined as an impairment of the bile flow which can lead to hepatocytes necrosis and finally cirrhosis. some studies reported a gastric acid secretion reduction in cirrhotic subjects, whi...

Introduction: Recently, hydrogen sulfide has been introduced as the third gas that acts as a transmitter. It has many physiological and pharmacological roles in the human body. The aim of the present study was to investigate the effect of exogenously administered and endogenously produced H2S on the basal and distention-induced gastric acid secretion in rats. Methods: Forty-nine male Wistar...

Objective(s): Transforming growth factor alpha (TGF-α) has been shown to modulate the gastric acid secretion. Therefore, the aim of the present study was to investigate the effect of sodium hydrosulfide (NaHS) on TGF-α expression in gastric mucosa in rats. Materials and Methods: Eighteen rats were randomly divided into 3 groups (6 per group). To determine the effect of NaHS on gene and protein ...

Background: Opioid peptides and their receptors are present in the majority of body tissues including gastrointestinal tract.  Heroin is one of the opioid derivatives that abuse increasingly today.  So far, there is no study on the effect of acute heroin administration on gastric acid and pepsin secretion. Objective:  To define the effect of the acute heroin consumption on basal and vagal-stimu...

objective(s) gastric ulceration is induced by various forms of stress like surgery, ischemia and trauma. the female sex has more resistance to stress and the gastrointestinal lesions happen fewer than male sex. the purpose of this study was to evaluate the role of estradiol and progesterone on the gastric acid and pepsin levels following traumatic brain injury (tbi) induction. materials and met...

background: gastric cancer is the fourth common malignancy and the second prevalent cause of cancer death in the world. genetic and environmental factors play an important role in the development of this cancer. nutritional and epidemiological studies have indicated that folate status modulates the risk of developing cancer and apoptosis has been reported to play a decisive role in precancerous...