The GTP-ase binding domain (GBD) of the signaling protein Wiskott-Aldrich Syndrome Protein (WASP) is intrinsically disordered and mutations in it have been linked with Wiskott-Aldrich Syndrome (WAS), an X-linked disorder characterized by thrombocytopenia, eczema and recurrent infections. Here, we use molecular dynamics simulations and the semi-empirical GROMOS 45A3 force field to study interact...

The aim of this study was to evaluate the effects of ginseng berry extract on insulin sensitivity and associated molecular mechanisms in aged mice. C57BL/6 mice (15 months old) were maintained on a regular diet (CON) or a regular diet supplemented with 0.05% ginseng berry extract (GBD) for 24 or 32 weeks. GBD-fed mice showed significantly lower serum insulin levels (p = 0.016) and insulin resis...

OBJECTIVE Dietary intake has long been looked upon as a potentially modifiable risk factor for gallbladder disease (GBD), here defined as either having gallstones or having had surgery for gallstones. This paper reviews the epidemiological evidence for an association between dietary intake and GBD, focusing on six dietary factors that have received the most attention in studies in this area: en...

BACKGROUND Pneumonia and diarrhea are leading causes of death for children under five (U5). It is challenging to estimate the total number of deaths and cause-specific mortality fractions. Two major efforts, one led by the Institute for Health Metrics and Evaluation (IHME) and the other led by the World Health Organization (WHO)/Child Health Epidemiology Reference Group (CHERG) created estimate...

The World Bank Group welcomes the publication of the new Global Burden of Disease Study (GBD). The Bank commissioned the fi rst GBD in 1990, and continues to make extensive use of this signal contribution to global health. Like its predecessors, the new, methodologically updated GBD 2010 marks a milestone in global health knowledge and our capacity for evidence-based action. It will once again ...

The Gröbner basis detection (GBD) is defined as follows: Given a set of polynomials, decide whether there exists -and if “yes” finda term order such that the set of polynomials is a Gröbner basis. This problem was shown to be NP-hard by Sturmfels and Wiegelmann. We show that GBD when studied in the context of zero dimensional ideals is also NP-hard. An algorithm to solve GBD for zero dimensiona...

1092 www.thelancet.com Vol 382 September 28, 2013 could be primarily due to diff erences in estimation methods. Compared with the methods based on direct observation that the four countries used, the GBD 2010 used a fi ve-step approach to estimate alcohol-related transport injury that was based on systematical review and synthesis of published and unpublished data because most countries lack hi...

Despite its biological importance, the interaction between fibronectin (FN) and collagen, two abundant and crucial tissue components, has not been well characterized on a structural level. Here, we analyzed the four interactions formed between epitopes of collagen type I and the collagen-binding fragment (gelatin-binding domain (GBD)) of human FN using solution NMR, fluorescence, and small angl...

EUS-guided gallbladder drainage (EUS-GBD) has been increasingly recognized as an effective treatment option for patients with acute cholecystitis who cannot undergo surgical cholecystectomy, alongside the historically traditional therapeutic options of percutaneous transhepatic (PT-GBD) and endoscopic retrograde cholangiopancreatography transpapillary (ETP-GBD).1Lee S.S. Park D.H. Hwang C.Y. et...

This essay asks whether the global burden of diseases, injuries, and risk factors (GBD) should be measured in terms of their consequences for health, as maintained by most of those who are attempting to measure the GBD, or in terms of their consequences for well-being, as argued by John Broome. It answers that the burden of disease should be understood in terms of the consequences of disease fo...