Positive and negative selection steps in the thymus prevent non-functional or harmful T cells from reaching the periphery. To examine the role of glucocorticoid (GC) hormone and its intracellular receptor (GCR) in thymocyte development we measured the GCR expression in different thymocyte subpopulations of BALB/c mice with or without previous dexamethasone (DX), anti-CD3 mAb, RU-486 and RU-4304...

BACKGROUND Proteinuria is a major predictor for progression of renal disease, including diabetic nephropathy. In a post hoc analysis of the ORIENT, a double-blinded randomized trial of 566 type 2 diabetic patients with nephropathy, we examined the risk association of composite renal outcome [end-stage renal disease, ESRD, doubling of serum creatinine (SCr) and death] with baseline, change and r...

In this paper we prove that there do not exist warped product GCR-lightlike submanifolds in the form M = N⊥ ×λ NT such that N⊥ is an anti-invariant submanifold tangent to V and NT an invariant submanifold of M̄ , other than GCR-lightlike product in an indefinite cosymplectic manifold. We also obtain some characterizations for a GCR-lightlike submanifold to be locally a GCR-lightlike warped produ...

We present a method to include watermarks in printed images. It does not degrade textures and has a high information channel capacity. With accurate printer calibration, in theory, the same color under different gray component replacement strategies (GCR) should look the same, under specific viewing conditions. We spatially vary the GCR along the image in a manner that is not perceptible, and w...

Copyright q 2012 Varun Jain et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. We define GCR-lightlike submanifolds of indefinite cosymplectic manifolds and give an example. Then, we study mixed geodesic GCR-lightlike submanif...

To decrease total body iodine is a key point in preparation for radioiodine study and therapy. We introduced a stringent self-managed low iodine diet (LID) and compared the outcome to that of the conventional restricted iodine diet (RID) for outpatients. We measured urine iodine to creatinine ratios (I/Cr) in patients prepared with RID for one week, LID for one week, or LID for two weeks. Mean ...

The main goal of this study is determination the effect of GCR (gray component replacement) levels on colorimetric characteristics of color proof. To determine the effect of GCR levels on colors of color proofs, a comparison of 2D and 3D color gamuts depending on GCR level have been performed. In addition to obtain better assessment of the effect of GCR levels on color gamut were calculate volu...

Identification of the signaling pathways that influence the reprogramming of Müller glia into neurogenic retinal progenitors is key to harnessing the potential of these cells to regenerate the retina. Glucocorticoid receptor (GCR) signaling is commonly associated with anti-inflammatory responses and GCR agonists are widely used to treat inflammatory diseases of the eye, even though the cellular...

BACKGROUND Glucocorticoid (GC) resistance is a major barrier in COPD treatment. We have shown increased expression of the drug efflux pump, Pgp1 in cytotoxic/pro-inflammatory lymphocytes in COPD. Loss of lymphocyte co-stimulatory molecule CD28 (lymphocyte senescence) was associated with a further increase in their pro-inflammatory/cytotoxic potential and resistance to GC. We hypothesized that l...