BACKGROUND Central pontine myelinolysis (CPM) is a demyelinating disorder of the central basis pontis that is often associated with osmotic stress. The aquaporin water channels (AQPs) have been pathogenically implicated because serum osmolarity changes redistribute water and osmolytes among various central nervous system compartments. RESULTS We characterized the immunoreactivity of aquaporin...

A spectrum of related malacic disorders called Simmental multifocal symmetrical encephalopathy have been reported in Simmental and Simmental crossbred cattle in Canada, Australia, and New Zealand. The cause of this condition is unknown. We describe multifocal polioencephalomyelomalacia in Simmental calves reared in Oregon, USA, with morphologic lesions similar to those described in Simmental mu...

Eight cases of CNS demyelinating pseudotumor were reported. The pathologic features and MR diagnostic value and limitation in this disease entity were discussed. MFU in 7 pathologically proved and 1 clinically proved cases of demyelinating pseudotumor were performed and retrospectively analyzed. The enhancement pattern of vertical distribution to the lateral ventricle was demonstrated, and dors...

SUMMARY: Smooth neuronal functioning requires an uninterrupted supply of energy that is provided by glucose under normal physiologic conditions. Significant variations in plasma glucose levels, be it hypoglycemia or hyperglycemia, can present with myriad clinical manifestations and may mimic stroke. At times, the diagnosis is either not apparent or not clinically suspected. Imaging can suggest ...